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Odonto-onycho-dermal dysplasia (OODD), a rare autosomal-recessive inherited form of ectodermal dysplasia including severe oligodontia, nail dystrophy, palmoplantar hyperkeratosis, and hyperhidrosis, was recently shown to be caused by a homozygous nonsense WNT10A mutation in three consanguineous Lebanese families. Here, we report on 12 patients, from 11(More)
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic(More)
Esthetically appealing, externally invisible, lingually applied orthodontic brackets are in increasing demand. Because the brackets are placed lingually, however, they appear to cause some problems with respect to speech. This study is the first to present a prospective evaluation of the articulation of 23 patients with lingual brackets by means of an(More)
Oral comfort, speech, mastication and swallowing, as well as oral hygiene were to be evaluated in a prospective longitudinal study before and after insertion of lingual brackets. 22 patients (five male, 17 female, mean age 34.7 years, SD 10.4) were enrolled in the study and filled in a standardized questionnaire directly before placement of lingual brackets(More)
Using a standardized questionnaire, 41 patients (12 men, 29 women; mean age 31.5 +/- 12.1 years) were interviewed prospectively on their subjective oral comfort, various oral functions, and professional qualification before indirect application of lingual brackets (T0), within 24 h of application (T1), and three months later (+/- 1 week) (T2). In 22 of the(More)
BACKGROUND Head & Face Medicine (HFM) was launched in August 2005 to provide multidisciplinary science in the field of head and face disorders with an open access and open peer review publication platform. The objective of this study is to evaluate the characteristics of submissions, the effectiveness of open peer reviewing, and factors biasing the(More)
The purpose of this prospective, longitudinal study was to compare the influence of two lingual bracket systems on subjective oral comfort, speech, mastication and oral hygiene. Forty-two native speakers of standard German (32 females, 10 males; mean age 27.1 years, standard deviation 12.2) were enrolled and completed a standardized questionnaire directly(More)
This study was aimed at determining the influence of a battery-operated interdental cleaning device (icd) (WaterPik Flosser) on the oral hygiene of 32 female right-handed patients (mean age 25.9 years) with lingual brackets in the upper (n = 29) and or in the lower arch (n = 25). Approximal plaque index (API) and bleeding on probing (BOP) were recorded at(More)
BACKGROUND Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified. METHODS Here, we report the results of a genome-wide association study of lithium response in(More)
BACKGROUND The goal of the Berlin Algorithm Project is to establish a standardized stepwise drug treatment regimen (SSTR) for the treatment of inpatients with depressive disorders. We are reporting on the first of 3 subsequent study phases evaluating effectiveness and feasibility of the SSTR in a naturalistic clinical setting. METHOD Patients with(More)