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Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms
Leptin (encoded by Lep) controls body weight by regulating food intake and fuel partitioning. Obesity is characterized by leptin resistance and increased endocannabinoid tone. Here we show thatExpand
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Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice.
BACKGROUND & AIMS Obesity-related insulin resistance contributes to cardiovascular disease. Cannabinoid receptor-1 (CB(1)) blockade improves insulin sensitivity in obese animals and people,Expand
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Brain insulin controls adipose tissue lipolysis and lipogenesis.
White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading to insulin resistanceExpand
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Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.
Circulating branched-chain amino acid (BCAA) levels are elevated in obesity/diabetes and are a sensitive predictor for type 2 diabetes. Here we show in rats that insulin dose-dependently lowersExpand
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Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice.
Cachexia, defined as an involuntary weight loss ≥ 5%, is a serious and dose-limiting side effect of chemotherapy that decreases survival in cancer patients. Alterations in lipid metabolism areExpand
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Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism
Fatty acids released from white adipose tissue (WAT) provide important energy substrates during fasting. However, uncontrolled fatty acid release from WAT during non-fasting states causesExpand
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Short Term Voluntary Overfeeding Disrupts Brain Insulin Control of Adipose Tissue Lipolysis*
Background: Insulin suppresses lipolysis through direct effects on adipocytes and indirectly through its neuronal receptors by reducing sympathetic outflow to adipose tissue. Results: Three-dayExpand
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Binge Drinking Induces Whole-Body Insulin Resistance by Impairing Hypothalamic Insulin Action
Rats given alcohol to simulate binge drinking exhibit the first signs of diabetes, a result of altered insulin action in the brain. Worse than a Hangover For some college students, getting hammeredExpand
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Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain
Hepatic steatosis is common in obesity and insulin resistance and results from a net retention of lipids in the liver. A key mechanism to prevent steatosis is to increase secretion of triglyceridesExpand
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CD8+ T cells induce cachexia during chronic viral infection
Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections. Understanding of the mechanisms that drive cachexia has remained limited,Expand
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