Thomas S. Kickler

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BACKGROUND Both inherited predisposition and platelet hyperreactivity have been associated with ischemic coronary events, but mechanisms that support genetic differences among platelets from different subjects are generally lacking. Associations between the platelet Pl(A2) polymorphism of GP IIIa and coronary syndromes raise the question as to whether this(More)
University of Florida (Quality control laboratory for platelet and white cell counting) ABSTRACT A variety of patient and product related factors influenced the outcome of 6,379 transfusions given to 533 patients in the Trial to Reduce Alloimmunization to Platelets (TRAP Trial). Responses measured were platelet increments, interval between platelet(More)
BACKGROUND Growing evidence suggests that vitamin D deficiency Is associated with clinical coronary artery disease (CAD). The relationship between vitamin D deficiency and subclinical CAD in HIV-infected individuals is not well-characterized. METHODS Computed tomographic (CT) coronary angiography was performed using contrast-enhanced 64-slice(More)
We evaluated an automated method (XE-2100 automated blood cell counter equipped with a laser and upgraded software, Sysmex, Kobe, Japan) to quantify the high fluorescent platelet fraction percentage (HFPF%) as an indicator of platelet production. The mean HFPF% value was 3.1 in 80 healthy subjects (95% confidence interval, 2.8%-3.5%). The coefficient of(More)
  • R Iannone, L Luznik, +9 authors E J Fuchs
  • 2001
Sickle cell anemia (SCA) is an inherited disorder of beta-globin, resulting in red blood cell rigidity, anemia, painful crises, organ infarctions, and reduced life expectancy. Allogeneic blood or marrow transplantation (BMT) can cure SCA but is associated with an 8% to 10% mortality rate, primarily from complications of marrow-ablative conditioning.(More)
BACKGROUND Point-of-care testing (POCT) can provide rapid test results, but its impact on patient care is not well documented. We investigated the ability of POCT to decrease inpatient and outpatient waiting times for cardiovascular procedures. METHODS We prospectively studied, over a 7-month period, 216 patients requiring diagnostic laboratory testing(More)
OBJECTIVE The objective of the study was to examine placental histopathology in intravenous immunoglobulin-treated and untreated neonatal alloimmune thrombocytopenia and correlate pathological findings with clinical outcomes. STUDY DESIGN Placentas from 14 neonatal alloimmune thrombocytopenia-affected pregnancies were identified. Maternal antepartum(More)
BACKGROUND Persistent thromboxane (TX) generation while receiving aspirin therapy is associated with an increased risk of cardiovascular events. The Reduction in Graft Occlusion Rates (RIGOR) study found that aspirin-insensitive TXA2 generation, indicated by elevated urine 11-dehydro-TXB2 (UTXB2) 6 months after coronary artery bypass graft surgery, was a(More)
Amino acid substitutions in platelet membrane glycoproteins result in alloantigens. Identifying these polymorphisms is important in alloimmune-mediated platelet disorders. Immunophenotyping platelet antigens can be limited by the unavailability of specific antisera. The goal of this work was to identify human platelet antigen genotypes in individuals using(More)
BACKGROUND The key objectives of this study were to examine whether HIV infection itself is associated with subclinical coronary atherosclerosis and the potential contributions of cocaine use and antiretroviral therapies (ARTs) to subclinical coronary artery disease (CAD) in HIV-infected persons. METHODS AND RESULTS Between June 2004 and February 2015,(More)