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We conducted an assessment of respiratory health status including questionnaire and spirographic measurements in 54 male swine producers age 36.3 +/- 11.1 years (mean +/- SD) who worked an average of 10.7 +/- 6.3 years in the industry and spent 4.7 +/- 2.1 hours per day in the swine barns, and we also measured atmospheric contaminants including carbon(More)
We conducted a longitudinal study to determine the annual rate decline in pulmonary function measurements in male swine confinement workers. For comparison, a grain farming group and a nonfarming rural-dwelling control group were also chosen for the longitudinal study. Two hundred seventeen swine confinement workers, 218 grain farmers, and 179 nonfarming(More)
A crossover trial was conducted to evaluate the acute human health effects of a dust control technology in a swine confinement facility. Twenty lifetime nonsmoking male subjects, with no evidence of allergy or asthma and no previous swine barn exposure, participated in the study, which included a laboratory session (baseline), 5-h exposure in a swine room(More)
OBJECTIVES We tested whether nitric oxide scavenging with a ruthenium-based compound (AMD6221) would improve hemodynamics and alter nitric oxide synthase and matrix metalloproteinase activities in a canine model of cardiopulmonary bypass. METHODS Dogs were randomized to either cardiopulmonary bypass (n = 12) or control (n = 12) groups. They were further(More)
OBJECTIVES Heart function is variably impaired after cardiopulmonary bypass. We hypothesized that, similar to other myocardial injury states, cardiopulmonary bypass leads to enhanced activity of nitric oxide synthase and matrix metalloproteinases. METHODS We obtained right atrial biopsy specimens and plasma samples at the onset and termination of(More)
OBJECTIVES Hemodynamic instability and generalized organ dysfunction are common after cardiopulmonary bypass in human beings. Previous studies have suggested that alterations of nitric oxide metabolism may be associated with this impaired function. Using a canine model we tested whether nitric oxide synthase activity is increased after cardiopulmonary(More)
BACKGROUND It has been shown that exposure in intense exposure in swine barn facilities is associated with increased respiratory symptoms and reduction in pulmonary functions. This study investigated if systemic response could be predicted by FEV(1) response following swine barn exposure. METHODS Naïve males were tested at baseline, low and high endotoxin(More)
In this report, we compare the respiratory health of swine producers, grain farmers, and nonfarming control subjects, separately in all age groups and in young subjects. We examined 249 swine producers (age 37.7 years), 251 grain farmers (age 44.7 years), and 263 nonfarming subjects (age 40.7 years). Swine producers had significantly more symptoms of(More)
BACKGROUND Swine farmers are exposed to a number of airborne contaminants associated with respiratory ill health. OBJECTIVES To examine the factors associated with healthy worker effect in the swine industry from a longitudinal follow-up of farmers at 4 years and 13 years. DESIGN A prospective study of swine farmers and nonexposed rural residents was(More)
OBJECTIVE To determine whether poultry production methods impact respiratory health, and whether poultry farmers have more respiratory symptoms and lower lung function than comparison control groups. DESIGN Cross-sectional study. SETTING Provinces of Saskatchewan, Alberta and Manitoba during the winters of 1997 to 1999. POPULATION Three hundred three(More)