Thomas Reinehr

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  • J Lindström, A Neumann, +90 authors T Yilmaz
  • Hormone and metabolic research = Hormon- und…
  • 2010
When we ask people what they value most, health is usually top of the list. While effective care is available for many chronic diseases, the fact remains that for the patient, the tax payer and the whole of society: prevention is better than cure. Diabetes and its complications are a serious threat to the survival and well-being of an increasing number of(More)
Meta-analyses of population-based genome-wide association studies (GWAS) in adults have recently led to the detection of new genetic loci for obesity. Here we aimed to discover additional obesity loci in extremely obese children and adolescents. We also investigated if these results generalize by estimating the effects of these obesity loci in adults and in(More)
BACKGROUND The prevalence and socioeconomic burden of type 2 diabetes (T2DM) and associated co-morbidities are rising worldwide. AIMS This guideline provides evidence-based recommendations for preventing T2DM. METHODS A European multidisciplinary consortium systematically reviewed the evidence on the effectiveness of screening and interventions for T2DM(More)
BACKGROUND The skeleton is regarded recently as an endocrine organ that affects energy metabolism. However, there are very limited data available concerning the relationships between the osteoblast-derived hormone osteocalcin, weight status, adiponectin and leptin in obese humans, especially in children. METHODS We analyzed osteocalcin, adiponectin,(More)
OBJECTIVE The study tested whether a combined environmental and educational intervention solely promoting water consumption was effective in preventing overweight among children in elementary school. METHODS The participants in this randomized, controlled cluster trial were second- and third-graders from 32 elementary schools in socially deprived areas of(More)
BACKGROUND The atherogenic risk factor profile in obese subjects is characterised by hypertension, reduced high density lipoprotein (HDL) cholesterol, increased low density lipoprotein (LDL) cholesterol and triglycerides, and insulin resistance. AIMS To examine the amount of weight reduction required to improve the atherogenic profile. METHODS Changes(More)
CONTEXT There are very limited data available concerning the relationships between fetuin-A, weight status, nonalcoholic fatty liver disease (NAFLD), and features of the metabolic syndrome (MetS) in obese humans, and especially in children. OBJECTIVE Our objective was to study the longitudinal relationships between fetuin-A, NAFLD, and MetS in obese(More)
A moderate elevation of thyrotropin (TSH) concentrations, which is associated with triiodothyronine (T3) values in or slightly above the upper normal range, is frequently found in obese humans. These alterations seem rather a consequence than a cause of obesity since weight loss leads to a normalization of elevated thyroid hormone levels. Elevated thyroid(More)
CONTEXT The gut hormone peptide YY(3-36) (PYY) reduces food intake via hypothalamic Y2 receptors in the brain. There is not much known about PYY in obese children. OBJECTIVE The objective of this study was to investigate the role of PYY in the metabolic changes in obese children and its change during weight loss. SETTING The study was performed at a(More)
CONTEXT There is some controversy whether T(4) treatment is indicated in obese humans with hyperthyrotropinemia. OBJECTIVE The objective of this study was to examine whether hyperthyrotropinemia is a cause or a consequence of obesity. DESIGN The study was designed as a cross-sectional comparison between obese and lean children and includes a 1-yr(More)