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The human alpha7 neuronal nicotinic acetylcholine receptor gene (HGMW-approved symbol CHRNA7) has been characterized from genomic clones. The gene is similar in structure to the chick alpha7 gene with 10 exons and conserved splice junction positions. The size of the human gene is estimated to be larger than 75 kb. A putative promoter 5' of the translation(More)
  • T R Moore
  • 1997
Amniotic fluid volume estimation has become an integral part of fetal evaluation. Although the sonographic techniques clinically available are limited in their accuracy and predictive value, the careful performance of AFI measurements provide important and complementary clinical data on which to base management decisions in pregnancies at risk.
The four-quadrant sum of amniotic fluid pockets (amniotic fluid index) was studied prospectively in 791 normal pregnancies. Interobserver and intraobserver variation was 3.1% and 6.7%, respectively. Logarithmic transformations were used to establish the mean and 90% confidence intervals for the amniotic fluid index at each week of gestation. In term(More)
OBJECTIVE The objective of the study was to compare outcomes between patients who did and did not receive preoperative uterine artery balloon catheters in the setting placenta accreta. STUDY DESIGN This was a retrospective case-control study of patients with placenta accreta from 1990 to 2011. RESULTS Records from 117 patients with pathology-proven(More)
OBJECTIVE To estimate the effects of prenatal diagnosis and delivery planning on outcomes in patients with placenta accreta. METHODS A review was performed of all patients with pathologically confirmed placenta accreta at the University of California, San Diego Medical Center from January 1990 to April 2008. Cases were divided into those with and without(More)
OBJECTIVE To determine whether antepartum variables can predict postpartum glucose intolerance. METHODS Glucose tolerance was assessed 6 weeks postpartum in 94 of 238 women with gestational diabetes using a 2-hour, 75-g oral glucose tolerance test (GTT). Selected antepartum variables were analyzed for predictive ability for postpartum glucose intolerance.(More)
Linkage of a neurophysiological deficit associated with schizophrenia, i.e., the failure to inhibit the auditory P50 response, was previously reported at chromosome 15q14. The marker with the highest pairwise lod score, D15S1360, was isolated from a yeast artificial chromosome containing a candidate gene, the alpha7-nicotinic acetylcholine receptor gene. In(More)
Fetal death is a tragedy for mother, family, and obstetrician. Recent reviews of fetal death indicate that nearly half occur in pregnancies that are not candidates for traditional antepartum testing. We conducted a prospective evaluation of the effectiveness of a fetal movement screening program in reducing the fetal mortality rate. During a 7-month control(More)
OBJECTIVES To define the profile of 24-hour uterine activity in normal pregnancy and to correlate contraction frequency with physical activity and emotional stress diaries. METHODS One hundred nine low-risk pregnant women who delivered at term recorded uterine contractions for 24 hours twice weekly from 20-40 weeks' gestation using an ambulatory monitor(More)
Acardiac twinning affects 1 in 100 monozygotic twin pregnancies and 1 in 35,000 pregnancies overall. The presence of an acadiac twin requires the normal (or "pump") twin to provide circulation for itself, as well as the acardiac sibling. In many cases the acardiac twin is almost equal to the normal twin. The principal perinatal problems associated with(More)