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Structural genomics seeks to expand rapidly the number of protein structures in order to extract the maximum amount of information from genomic sequence databases. The advent of several large-scale projects worldwide leads to many new challenges in the field of crystallographic macromolecular structure determination. A novel software package called PHENIX(More)
Emotions are an important aspect of human intelligence and have been shown to play a significant role in the human decision-making process. Researchers in areas such as cognitive science, philosophy, and artificial intelligence have proposed a variety of models of emotions. Most of the previous models focus on an agent's reactive behavior, for which they(More)
Psychological studies on teamwork have shown that an effective team often can anticipate information needs of teammates based on a shared mental model. Existing multi-agent models for teamwork are limited in their ability to support proactive information exchange among teammates. To address this issue, we have developed and implemented a multi-agent(More)
Learning users' interest categories is challenging in a dynamic environment like the Web because they change over time. This paper describes a novel scheme to represent a user's interest categories, and an adaptive algorithm to learn the dynamics of the user's interests through positive and negative relevance feedback. We propose a three-descriptor model to(More)
A new software system called PHENIX (Python-based Hierarchical ENvironment for Integrated Xtallography) is being developed for the automation of crystallographic structure solution. This will provide the necessary algorithms to proceed from reduced intensity data to a refined molecular model, and facilitate structure solution for both the novice and expert(More)
TEXTAL is an automated system for building protein structures from electron-density maps. It uses pattern recognition to select regions in a database of previously determined structures that are similar to regions in a map of unknown structure. Rotation-invariant numerical values, called features, of the electron density are extracted from spherical regions(More)
The pathways that comprise cellular metabolism are highly interconnected, and alterations in individual enzymes can have far-reaching effects. As a result, global profiling methods that measure gene expression are of limited value in predicting how the loss of an individual function will affect the cell. In this work, we employed a new method of global(More)
Tuberculosis poses a global health emergency, which has been compounded by the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains. We used whole-genome sequencing to compare the accumulation of mutations in Mtb isolated from cynomolgus macaques with active, latent or reactivated disease. We sequenced 33 Mtb isolates from nine macaques with(More)
The emergence of, what is now called, 'emotional intelligence' has revealed yet another aspect of human intelligence. Emotions were shown to have a major impact on many of our everyday tasks, including decision-making, planning, communication, and behavior. Researchers have recently acknowledged this major role that emotions play, and thus we see a variety(More)
Over 30% of the world's population is infected with Mycobacterium tuberculosis (Mtb), yet only ~5–10% will develop clinical disease 1. Despite considerable effort, we understand little about what distinguishes individuals who progress to active tuberculosis (TB) from those who remain latent for decades. The variable course of disease is recapitulated in(More)