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Cardiovascular Risks in Patients with COVID-19: Potential Mechanisms and Areas of Uncertainty
Purpose of Review COronaVirus Disease 2019 (COVID-19) has spread at unprecedented speed and scale into a global pandemic with cardiovascular risk factors and complications emerging as importantExpand
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Genetics and Genomics of Coronary Artery Disease
Coronary artery disease (or coronary heart disease), is the leading cause of mortality in many of the developing as well as the developed countries of the world. Cholesterol-enriched plaques in theExpand
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Vulnerabilities of transcriptome-wide association studies
Transcriptome-wide association studies (TWAS) integrate GWAS and expression quantitative trait locus (eQTL) datasets to discover candidate causal gene-trait associations. We integrate multi-tissueExpand
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TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression
BackgroundGenome-wide association studies have identified over 160 loci that are associated with coronary artery disease. As with other complex human diseases, risk in coronary disease loci isExpand
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Replication of genome‐wide association signals of type 2 diabetes in Han Chinese in a prospective cohort
Background  A recent genome‐wide association study for type 2 diabetes in Han Chinese identified several novel genetic variants. We investigated their associations with quantitative measures toExpand
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Transcriptome-wide association studies: opportunities and challenges
Transcriptome-wide association studies (TWAS) integrate GWAS and gene expression datasets to find gene-trait associations. In this Perspective, we explore properties of TWAS as a potential approachExpand
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Dissecting the Causal Genetic Mechanisms of Coronary Heart Disease
Large-scale genome-wide association studies (GWAS) have identified 46 loci that are associated with coronary heart disease (CHD). Additionally, 104 independent candidate variants (false discoveryExpand
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Genetic Structure of Human Populations
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Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
D.S. has received support from NHLBI, NINDS, Pfizer, Regeneron Pharmaceuticals, Genentech, and Eli Lilly. Genotyping in PROMIS was funded by the Wellcome Trust, UK, and Pfizer. Biomarker assays inExpand
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