Thomas Prasch

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The solution structure of the tetracyclic lantibiotic mersacidin in methanol (CD3OH) has been determined by NMR followed by distance bound driven dynamics and subsequent restrained molecular dynamics simulations combined with an iterative relaxation matrix approach and alternatively by a simulated annealing protocol. The molecular dynamics simulations were(More)
A new experimental mixing scheme for band-selective Hartmann-Hahn transfer between the HN and H alpha resonances of peptides and proteins is presented. This form of tailored correlation spectroscopy (TACSY) allows enhancement of the sensitivity of specific (HN-H alpha)-fingerprint signals compared to broadband TOCSY experiments. The design criteria as well(More)
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