Thomas P. Matthews

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Inhibitors of checkpoint kinase 1 (CHK1) are of current interest as potential antitumor agents, but the most advanced inhibitor series reported to date are not orally bioavailable. A novel series of potent and orally bioavailable 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitrile CHK1 inhibitors was generated by hybridization of two lead scaffolds(More)
Editorial In this issue (1) David Montefiori and his colleagues have demonstrated both how far we have come since Margaret Heckler's 1984 prediction of an AIDS vaccine within 24 months, and how far we have to go before this promise is realized. This work extends to human vaccine trials' earlier observations related to the cooperativity in neutralization(More)
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