Thomas P.A. Debray

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OBJECTIVES Individual participant data (IPD) meta-analyses often analyze their IPD as if coming from a single study. We compare this approach with analyses that rather account for clustering of patients within studies. STUDY DESIGN AND SETTING Comparison of effect estimates from logistic regression models in real and simulated examples. RESULTS The(More)
BACKGROUND Risk prediction models estimate the risk of developing future outcomes for individuals based on one or more underlying characteristics (predictors). We review how researchers develop and validate risk prediction models within an individual participant data (IPD) meta-analysis, in order to assess the feasibility and conduct of the approach. (More)
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