Thomas N. Hwang

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Spontaneous inhibitory and excitatory postsynaptic currents (sIPSCs and sEPSCs) were identified and characterized with whole cell and perforated patch voltage-clamp recordings in adult mouse retinal ganglion cells. Pharmacological dissection revealed that all cells were driven by spontaneous synaptic inputs mediated by glutamate and gamma-aminobutyric(More)
Evisceration is an ophthalmic surgery that removes the internal contents of the eye followed usually by placement of an orbital implant to replace the lost ocular volume. Unlike enucleation, which involves removal of the entire eye, evisceration potentially causes exposure of uveal antigens; therefore, historically there has been a concern about sympathetic(More)
Lupus erythematosus profundus (LEP) is an uncommon subtype of lupus erythematosus. A 76-year old man presented with inflammation of the eyelids and underlying orbital soft tissue. A biopsy disclosed inflammation and atrophy of the orbital fat consistent with LEP. Systemic corticosteroid treatment produced resolution of the inflammation. but as the edema(More)
Rapid and reliable detection of randomly occurring small amplitude synaptic events resulting from activation of different classes of ligand-gated receptors is a difficult task. Here, we describe and characterize an amplitude threshold algorithm, written as an IGOR Pro procedure, which detects events as well as characterizes their amplitudes and kinetics.(More)
A 41-year-old woman presented with a 21-year history of a left orbital mass. She reported 3 distinct episodes of sudden proptosis, periorbital bruising, pain, nausea and vomiting with resulting stepwise deterioration in her vision. Her symptoms resolved spontaneously over several days, with the exception of loss in vision, which persisted. Examination was(More)
Brain-derived neurotrophic factor (BDNF) can potentiate synaptic release at newly developed frog neuromuscular junctions. Although this potentiation depends on extracellular Ca(2+) and reflects changes in acetylcholine release, little is known about the intracellular transduction or calcium signaling pathways. We have developed a video assay for(More)
BACKGROUND Giant cell arteritis (GCA) is a common systemic vasculitis, with a presumed Caucasian predominance. The occurrence of GCA in Asians has rarely been addressed. This study aims to assess the incidence of giant cell arteritis in Asians. METHODS In this retrospective review, the self-reported ethnicities of patients with biopsy-proven GCA at the(More)
PURPOSE To explain the mechanism for acquired enophthalmos after ventriculoperitoneal shunting (VPS). DESIGN Case series and a case-control study. PARTICIPANTS AND CONTROLS Four study patients with bilateral enophthalmos after VPS and 10 control subjects. METHODS Case description of 4 study patients. Calculated orbital volumes for 2 study patients(More)
Trapdoor fractures occur almost exclusively in the pediatric population. The authors describe an adult with an entrapped inferior rectus muscle sheath in a trapdoor fracture. A 37-year-old man presented with persistent diplopia 3 weeks after blunt right orbital trauma. The only abnormal findings on clinical examination were limited vertical ductions. No(More)
PURPOSE To report an unusual case of optic nerve seeding 12 years following treatment of a suprasellar germinoma. METHODS Observational case report. RESULTS A 34-year-old woman presented with a 3-week history of subjective right eye visual loss. She had been diagnosed with a suprasellar germinoma at 22 years of age, which had been partially excised and(More)