Thomas Mulligan

Charles Jacobson1
Brian V Shenal1
Hubert H Fernandez1
Gregory Crucian1
1Charles Jacobson
1Brian V Shenal
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  • Michael S Okun, Hubert H Fernandez, Ramon L Rodriguez, Janet Romrell, Michele Suelter, Sarah Munson +8 others
  • 2006
BACKGROUND Testosterone deficiency has been reported in patients with Parkinson disease (PD), Alzheimer disease, and Huntington disease. It is not known whether testosterone therapy (TT) in men with borderline hypogonadism and neurodegenerative diseases will be of substantial benefit. Previously, we reported that testosterone deficiency is more common in(More)
Despite intensive research on testosterone therapy for older men, important questions remain unanswered. The evidence clearly indicates that many older men display a partial androgen deficiency. In older men, low circulating testosterone is correlated with low muscle strength, with high adiposity, with insulin resistance and with poor cognitive performance.(More)
Healthy older men manifest combined declines in testosterone concentrations, LH secretory burst mass (amount of LH released per pulse), and feedback-sensitive regularity of unknown cause. To test a unifying hypothesis of simultaneous reductions in GnRH outflow, gonadotrope responsiveness to GnRH, and androgenic negative feedback, we monitored LH secretion(More)
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