Thomas Moder

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OBJECTIVE This prospective study evaluated clinical risk indicators as well as pro- and anti- inflammatory mediators at the time of malignancy diagnosis in relation to chemotherapy-related oral mucositis in pediatric population. METHODS Patients (n = 104) under 18 years of age with primary malignancies and undergoing chemotherapy were included. Potential(More)
The role of oral bacteria in the development of chemotherapy-related oral mucositis has not been fully elucidated. This study aimed to investigate oral bacterial community diversity and dynamics in paediatric patients with malignancies in relation to the occurrence of oral mucositis. Patients with malignancies (n = 37) and reference individuals without(More)
BACKGROUND Patients with severe congenital neutropenia (SCN) often develop periodontitis despite standard medical and dental care. In light of previous findings that mutations in the neutrophil elastase gene, ELANE, are associated with more severe neutropenic phenotypes, we hypothesized an association between the genotype of SCN and development of(More)
BACKGROUND Prostaglandin E2 (PGE2) is involved in several chronic inflammatory diseases including periodontitis, which causes loss of the gingival tissue and alveolar bone supporting the teeth. We have previously shown that tumor necrosis factor alpha (TNFalpha) induces PGE2 synthesis in gingival fibroblasts. In this study we aimed to investigate the global(More)
The underlying cause of neutropenia may be difficult to determine due to similar clinical presentation in many neutropenic conditions. The neutrophil protein hCAP-18 (pro-LL-37) is a major component of neutrophil secondary granules and in this prospective study we assessed the use of hCAP-18 levels in blood plasma for differential diagnosis of neutropenic(More)
The relationship between sucking habits and dental characteristics of unilateral cross-bite in 4-yr-old children (n = 76) was studied. The cross-bites were classified on the variables "number of teeth involved", incisor "overjet" and "overbite", "terminal plane shift", "midline shift", "asymmetric maxillary dental arch" and "max./mand. arch width(More)
— Since state-of-the-art smartphones do usually not comprise barometers, ubiquitous 3D indoor positioning requires a compensation of the missing height information. A pedestrian activity classification (PAC) algorithm enabling the activity detection of going up-or downstairs can deliver this missing information. Additionally, this PAC can be used for the(More)