Thomas Mitchell

Learn More
BACKGROUND Cannabinoid use could potentially alter HIV RNA levels by two mechanisms: immune modulation or cannabinoid-protease inhibitor interactions (because both share cytochrome P-450 metabolic pathways). OBJECTIVE To determine the short-term effects of smoked marijuana on the viral load in HIV-infected patients. DESIGN Randomized,(More)
There is evidence from the SNARC (spatial-numerical association of response codes) effect and NDE (numerical distance effect) that number activates spatial representations. Most of this evidence comes from tasks with explicit reference to number, whether through presentation of Arabic digits (SNARC) or through magnitude decisions to nonsymbolic(More)
BACKGROUND AND OBJECTIVE Asthma and allergic rhinitis are significant, increasing causes of morbidity worldwide. Pollen, a major cause of seasonal rhinitis/conjunctivitis, carries proteolytic enzymes on its surface. We showed previously that peptidase allergens from house dust mites compromise epithelial barrier function by degrading the extracellular(More)
There is a large body of accumulated evidence from behavioral and neuroimaging studies regarding how and where in the brain we represent basic numerical information. A number of these studies have considered how numerical representations may differ between individuals according to their age or level of mathematical ability, but one issue rarely considered(More)
To determine if providers experienced in the management of human immunodeficiency virus (HIV) disease preferred different treatment regimens than providers with less experience, we analyzed data from a national survey of primary care providers' preferred regimens for the management of 30 HIV-related medical conditions. We mailed questionnaires to 999(More)
We have previously demonstrated that continuous exposure of human HL-60 human promyelocytes to 1-fl-D-arabinofuranosylcytosine (araC) results in the induction of terminal differentiation to monocyte-like cells. The present study extends these findings by demonstrating that ara-C induces hemoglobin synthesis in human K562 erythroleukemia cells. This effect(More)
We wished to determine the extent to which drugs used to treat HIV disease and its clinical manifestations are prescribed for conditions other than those listed on the U.S. Food and Drug Administration's approved drug label, how such "off-label" use varies by patient characteristics and type of HIV-related medical condition, and the extent to which(More)
A randomized, prospective, open-label, treatment versus no treatment community-based clinical trial was conducted to evaluate the safety and efficacy of clofazimine as prophylaxis for disseminated Mycobacterium avium complex (MAC) infection in patients with human immunodeficiency virus (HIV) disease. Subjects were 110 patients with a first episode of(More)