Thomas Mey

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2-[(2-Methoxy-4-methylsulfinyl) phenyl]-iH-imidazo[4,5-b]pyridine (AR-L 115 BS), 0.7 mg/kg, was compared to dobutamine, 0.01 mg/kg, and placebo after i.v. administration in a double-blind cross-over study in healthy subjects. The systolic time intervals, the blood pressure and the heart rate were used as a measure of efficacy. Both substances caused a(More)
In the present report a score system is introduced with the aim of analysing routine angiographic images. The system consists of a vectorial score, which codes the pattern of occlusions, stenoses and plaques, and of an additive score describing the severity of the lesions visualised. The technique is suitable for computerised data analysis.
In a double-blind cross-over study in 8 normotensive subjects azepexole was found to have a pharmacological profile identical to that of clonidine, although chemically there is no structural similarity between the two compounds. Compared to placebo, oral azepexole 5 and 10 mg and clonidine 0.15 mg produced a significant reduction in systolic and diastolic(More)
The purpose of the study conducted was to clarify the question of chronic, systemic toxicity from PUVA therapy. Five groups of patients, classified according to length of treatment were examined with respect to 43 laboratory parameters. The results indicated that PUVA had no chronic toxic influence on the liver, kidneys, bone marrow, metabolism, or immune(More)
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