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Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in approximately 11% of tumors. Additionally,(More)
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological(More)
With the ever present threat to commerce, both politically and economically, technological innovations provide a means to secure the transportation infrastructure that will allow efficient and uninterrupted freight-flow operations for trade. Currently, freight coming into United States ports is " spot checked " upon arrival and stored in a container yard(More)
With over 360 ports of entry and 20 million sea, truck, and rail containers entering the United States every year, port facilities pose a large risk to security. Securing these ports and monitoring the variety of traffic that enter and leave is a major task. To accomplish this, the authors propose a fully distributed building block approach to port(More)