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The force exerted by skeletal muscle is modulated by compliance of tissues to which it is connected. Force of the muscle sarcomere is modulated by compliance of the myofilaments. We tested the hypothesis that myofilament compliance influences Ca2+ regulation of muscle by constructing a computational model of the muscle half sarcomere that includes(More)
To assess the extent to which the power output of a synchronous insect flight muscle is maximized during flight, we compared the maximum potential power output of the mesothoracic dorsolongitudinal (dl1) muscles of Manduca sexta to their power output in vivo. Holding temperature and cycle frequency constant at 36 degrees C and 25 Hz, respectively, we varied(More)
The synchronous wing depressor muscles of the hawkmoth Manduca sexta undergo large amplitude motions at lengths that lie entirely on the ascending region of their twitch length-tension curve. Moreover, these muscles bear a striking functional resemblance to mammalian cardiac muscle in both the shape of their length-tension curve and in their working length(More)
Neuromechanics seeks to understand how muscles, sense organs, motor pattern generators, and brain interact to produce coordinated movement, not only in complex terrain but also when confronted with unexpected perturbations. Applications of neuromechanics include ameliorating human health problems (including prosthesis design and restoration of movement(More)
Flying insects have evolved sophisticated sensory capabilities to achieve rapid course control during aerial maneuvers. Among two-winged insects such as houseflies and their relatives, the hind wings are modified into club-shaped, mechanosensory halteres, which detect Coriolis forces and thereby mediate flight stability during maneuvers. Here, we show that(More)
Introduction Hawkmoths are adept flyers that typically hover, rather than perch, while feeding from flowers. The flowers on which they feed move in response to both natural air currents and those induced by the moth as it hovers. Indeed, the self-generated air flow from the beating wings of a hawkmoth is powerful (Sane and Jacobson, 2006) and capable of(More)
The halteres of dipteran insects are essential sensory organs for flight control. They are believed to detect Coriolis and other inertial forces associated with body rotation during flight. Flies use this information for rapid flight control. We show that the primary afferent neurons of the haltere's mechanoreceptors respond selectively with high temporal(More)
In muscle, force emerges from myosin binding with actin (forming a cross-bridge). This actomyosin binding depends upon myofilament geometry, kinetics of thin-filament Ca(2+) activation, and kinetics of cross-bridge cycling. Binding occurs within a compliant network of protein filaments where there is mechanical coupling between myosins along the(More)
Moving animals orchestrate myriad motor systems in response to multimodal sensory inputs. Coordinating movement is particularly challenging in flight control, where animals deal with potential instability and multiple degrees of freedom of movement. Prior studies have focused on wings as the primary flight control structures, for which changes in angle of(More)
Control theory arose from a need to control synthetic systems. From regulating steam engines to tuning radios to devices capable of autonomous movement, it provided a formal mathematical basis for understanding the role of feedback in the stability (or change) of dynamical systems. It provides a framework for understanding any system with regulation via(More)