Thomas L. Clarke

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Protein post-translation modification plays an important role in regulating DNA repair; however, the role of arginine methylation in this process is poorly understood. Here we identify the arginine methyltransferase PRMT5 as a key regulator of homologous recombination (HR)-mediated double-strand break (DSB) repair, which is mediated through its ability to(More)
Health departments, community-based organizations (CBOs), and AIDS service organizations (ASOs) in the United States and abroad distribute large quantities of free condoms to sexually active individuals; however, little is known about where individuals who use condoms actually acquire them. This community-based participatory research (CBPR) study was(More)
This paper reports on research aimed at providing a more realistic simulation model of crowd behavior under both panic and non-panic conditions by modifying the Helbing-Molnar-Farkas-Vicsek (HMFV) model. Such simulations will be of great value both in operational and training contexts. Many operations deal with crowd control and accurate simulations of(More)
Very few crowds consist of individuals who are exactly the same. Defining variables, such as age, and how they affect an individual's movement, could increase realism in simulations of crowd movement. In this paper, we present and discuss how age variations of individuals can be included in crowd simulations. Starting with the Helbing, Molnar, Farkas, and(More)
The technological revolution in high-throughput nucleic acid and protein analysis in the last 15 years has launched the field of 'omics' and led to great advances in our understanding of cell biology. Consequently the study of the cellular proteome and protein dynamics, in particular interactomics, has been a matter of intense investigation, specifically(More)
This article continues the discussions introduced in the earlier article submitted to The Health Care Manager that is titled Epidemic Simulation for Syndromic Surveillance, where a format for analysis of the incidence of a bioterrorist attack was presented. Part 2 of this series provides a discussion of the observed outcomes from the simulation techniques.(More)
This article reports on a project to develop a simulation-based test bed for the BioDefend Syndromic Surveillance System. BioDefend is a system that data mines syndrome reports from emergency rooms and so forth to produce early alerts of epidemic onset. An existing large-scale epidemic simulation will be adapted to provide synthetic reports of syndromes(More)
Benchmarks for parallel processing of large models is an urgent need for High Performance Computing (HPC) as today’s model size reaches millions of degrees of freedom. Explicit solvers as in the case of crash dynamics or fluid dynamics do not require matrix based equation solvers and inherently exhibit good scalability on large numbers of processors. Where(More)