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Proton and ion beams open up new vistas for the curative treatment of tumors, but adequate technologies for monitoring the compliance of dose delivery with treatment plans in real time are still missing. Range assessment, meaning the monitoring of therapy-particle ranges in tissue during dose delivery (treatment), is a continuous challenge considered a key(More)
Treedimensional in-vivo dose monitoring of ion beam cancer irradiation can improve the quality of treatment. For this purpose we investigate the feasibility of imaging the single photon emissions due to nuclear reactions of projectiles with target nuclei (in-beam SPECT). A suitable imaging technique in the energy range of the emitted gamma rays is the(More)
Proton therapy is an advantageous treatment modality compared to conventional radiotherapy. In contrast to photons, charged particles have a finite range and can thus spare organs at risk. Additionally, the increased ionization density in the so-called Bragg peak close to the particle range can be utilized for maximum dose deposition in the tumour volume.(More)
In the context of particle therapy, particle range verification is a major challenge for the quality assurance of the treatment. One approach is the measurement of the prompt gamma rays resulting from the tissue irradiation. A Compton camera based on several planes of position sensitive gamma ray detectors, together with an imaging algorithm, is expected to(More)
Irradiation with protons and light ions offers new possibilities for tumor therapy but has a strong need for novel imaging modalities for treatment verification. The development of new detector systems, which can provide an in vivo range assessment or dosimetry, requires an accurate knowledge of the secondary radiation field and reliable Monte Carlo(More)
Range verification is a very important point in order to fully exploit the physical advantages of protons compared to photons in cancer irradiation. Recently, a simple method has been proposed which makes use of the time of flight of protons in tissue and the promptly emitted secondary photons along the proton path (Prompt Gamma Timing, PGT). This has been(More)
A primary subject of the present research in particle therapy is to ensure the precise irradiation of the target volume. The prompt gamma timing (PGT) method provides one possibility for in vivo range verification during the irradiation of patients. Prompt gamma rays with high energies are emitted promptly due to nuclear reactions of protons with tissue.(More)
Positron emission tomography (PET) is a means of imaging the β+-activity produced by the radiation field in ion beam therapy and therefore for treatment verification. Prompt γ-rays that are emitted during beam application challenge the detectors and electronics of PET systems, since those are designed for low and medium count rates. Typical PET detectors(More)
Proton beams are promising means for treating tumors. Such charged particles stop at a defined depth, where the ionization density is maximum. As the dose deposit beyond this distal edge is very low, proton therapy minimizes the damage to normal tissue compared to photon therapy. Nevertheless, inherent range uncertainties cast doubts on the irradiation of(More)