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Many neurological and psychiatric disorders affect the cerebral cortex, and a clearer understanding of the molecular processes underlying human corticogenesis will provide greater insight into such pathologies. To date, knowledge of gene expression changes accompanying corticogenesis is largely based on murine data. Here we present a searchable,(More)
PURPOSE Numerous preclinical studies have shown that transplantation of stem cell-derived retinal pigment epithelial cell (RPE) preserves photoreceptor cell anatomy in the dystrophic Royal College of Surgeons (RCS) rat. How rescue is spatially distributed over the eye, relative to the transplantation site, is less clear. To understand spatial variations in(More)
Multielectrode arrays (MEA) are routinely used to observe the development of neuronal networks in vitro, making simultaneous recordings of small proximal sub-population activity within a cell culture. We propose the use of graph theoretic measures to deduce behavioral properties of neuronal networks as they develop in culture. We utilize 878 recordings from(More)
Multielectrode arrays (MEA) are broadly used for in vitro cell culture observation. Complete realization of this platform's potential to the study of disease and development depends on the capability to make 1) reliable and repeatable observations, 2) neuronal network behavior characterizations, and 3) meaningful comparisons between cultures. Using an(More)
We are interested in explaining neuronal network development through visualizations that summarize trends in large data. We utilized previously-recorded spiking patterns of embryonic rat cortex cells grown on multielec-trode arrays [1]. We present results for batch 1 culture 3. Recordings were divided into 100 17.7 s intervals (the time required to(More)
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