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  • Thomas K. H. Chang, Jiyun Chen, Wing Bun Lee
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2001 (First Publication: 1 December 2001)
  • trans-Resveratrol (3,5,4'-trihydroxy-trans-stilbene) has been reported to confer chemoprotection against 7,12-dimethylbenz[a]anthracene (DMBA)-induced carcinogenicity in a murine model. A potentialContinue Reading
  • Vincent Tong, Xiao Wei Teng, Thomas K. H. Chang, Frank S. Abbott
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of…
  • 2005 (First Publication: 1 August 2005)
  • A single dose of valproic acid (VPA), which is a widely used antiepileptic drug, is associated with oxidative stress in rats, as recently demonstrated by elevated levels of 15-F(2t)-isoprostaneContinue Reading
  • Thomas K. H. Chang, Jie Chen, Eugene Y. H. Yeung
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 2006 (First Publication: 1 May 2006)
  • In the present study, we investigated the effect of Ginkgo biloba extracts and some of its individual constituents on the catalytic activity of human cytochrome P450 enzymes CYP1B1, CYP1A1, andContinue Reading
  • Maria Isabel Ayrosa Madeira, Marc M. Levine, Thomas K. H. Chang, Ahmad Mirfazaelian, Gail D. Bellward
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2004 (First Publication: 1 April 2004)
  • Clinically, cimetidine therapy impairs the clearance of various drugs metabolized by CYP2D6, such as desipramine and sparteine. Cimetidine is known to reversibly inhibit CYP2D6 in vitro; however, KiContinue Reading
  • Vincent Tong, Xiao Wei Teng, Thomas K. H. Chang, Frank S. Abbott
  • Biology, Medicine
  • Toxicological sciences : an official journal of…
  • 2005 (First Publication: 1 August 2005)
  • Oxidative stress has been associated with valproic acid (VPA) treatment, and mitochondrial dysfunction has been implicated in the pathogenesis of VPA-idiosyncratic hepatotoxicity. The present studyContinue Reading
  • Tony K L Kiang, Ping C. Ho, M. Reza Anari, Vincent Tong, Frank S. Abbott, Thomas K. H. Chang
  • Medicine, Biology
  • Toxicological sciences : an official journal of…
  • 2006 (First Publication: 31 July 2006)
  • The present study investigated the role of specific human cytochrome P450 (CYP) enzymes in the in vitro metabolism of valproic acid (VPA) by a complementary approach that used individualContinue Reading