Thomas K. Harris

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The <i>personal universal controller</i> (PUC) is an approach for improving the interfaces to complex appliances by introducing an intermediary graphical or speech interface. A PUC engages in two-way communication with everyday appliances, first downloading a specification of the appliance's functions, and then automatically creating an interface for(More)
We introduce Olympus, a freely available framework for research in conversational interfaces. Olympus’ open, transparent, flexible, modular and scalable nature facilitates the development of large-scale, real-world systems, and enables research leading to technological and scientific advances in conversational spoken language interfaces. In this paper, we(More)
In Cognitive Tutors, student skill is represented by estimates of student knowledge on various knowledge components. The estimate for each knowledge component is based on a four-parameter model developed by Corbett and Anderson [Nb]. In this paper, we investigate the nature of the parameter space defined by these four parameters by modeling data from over(More)
A novel thermodynamically-balanced inside-out (TBIO) method of primer design was developed and compared with a thermodynamically-balanced conventional (TBC) method of primer design for PCR-based gene synthesis of codon-optimized gene sequences for the human protein kinase B-2 (PKB2; 1494 bp), p70 ribosomal S6 subunit protein kinase-1 (S6K1; 1622 bp) and(More)
Several industrial and academic research groups are working to simplify the control of appliances and services by creating a truly universal remote control. Unlike the preprogrammed remote controls available today, these new controllers download a specification from the appliance or service and use it to automatically generate a remote control interface.(More)
In protein and RNA macromolecules, only a limited number of different side-chain chemical groups are available to function as catalysts. The myriad of enzyme-catalyzed reactions results from the ability of most of these groups to function either as nucleophilic, electrophilic, or general acid-base catalysts, and the key to their adapted chemical function(More)
This research investigates the design and performance of the Speech Graffiti interface for spoken interaction with simple machines. Speech Graffiti is a standardized interface designed to address issues inherent in the current state-of-the-art in spoken dialog systems such as high word-error rates and the difficulty of developing natural language systems.(More)
We have compared hydrogen bond lengths on enzymes derived with high precision (< or = +/- 0.05 A) from both the proton chemical shifts (delta) and the fractionation factors (phi) of the proton involved with those obtained from protein X-ray crystallography. Hydrogen bond distances derived from proton chemical shifts were obtained from a correlation of 59(More)
The amino-terminal proline of 4-oxalocrotonate tautomerase (4-OT) functions as the general base catalyst in the enzyme-catalyzed isomerization of beta,gamma-unsaturated enones to their alpha,beta-isomers because of its unusually low pK(a) of 6.4 +/- 0.2, which is 3 units lower than that of the model compound, proline amide. Recent studies show that this(More)
In addition to its catalytic domain, phosphoinsositide-dependent protein kinase-1 (PDK1) contains a C-terminal pleckstrin homology (PH) domain, which binds the membrane-bound phosphatidylinositol (3,4,5)-triphosphate [PI(3,4,5)P3] second messenger. Here, we report in vitro kinetic, phosphopeptide mapping, and oligomerization studies that address the role of(More)