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problems of a complexity they never dreamed of in the early days of programming. Model-driven development 1,2 is a natural continuation of this trend. Instead of requiring developers to spell out every detail of a sys-tem's implementation using a programming language, it lets them model what functionality is needed and what overall architecture the system(More)
As the UML attempts to make the transition from a single , albeit extensible, language to a framework for a family of languages, the nature and form of the underlying meta-modeling architecture will assume growing importance. It is generally recognized that without a simple, clean and intuitive theory of how metamodel levels are created and related to one(More)
Metamodeling is one of the core foundations of computer-automated multiparadigm modeling. However, there is currently little agreement about what form the required metamodeling approach should take and precisely what role metamodels should play. This article addresses the problem by first describing some fundamental problems in the industry's leading(More)
Diagnosis and management of immune thrombocytopenic purpura (ITP) remain largely dependent on clinical expertise and observations more than on evidence derived from clinical trials of high scientific quality. One major obstacle to the implementation of such studies and in producing reliable meta-analyses of existing data is a lack of consensus on(More)
With the recent trend to model driven engineering a common understanding of basic notions such as " model " and " metamodel " becomes a pivotal issue. Even though these notions have been in widespread use for quite a while, there is still little consensus about when exactly it is appropriate to use them. The aim of this article is to start establishing a(More)
This pilot study tested feasibility of natural killer cell purification and infusion (NK-DLI) in patients after haploidentical hematopoietic stem cell transplantation (HSCT). The aim was to obtain >or=1.0 x 10(7)/kg CD56+/CD3- NK cells and <1.0 x 10(5)/kg CD3+ T cells. Mononuclear cells were collected by 10 l leukapheresis. A two-step ex vivo procedure was(More)
PURPOSE To evaluate patient and tumor characteristics, treatment, and outcomes in a large cohort of unselected patients with second and subsequent recurrences of osteosarcoma. PATIENTS AND METHODS Two hundred forty-nine consecutive patients who had originally received combined-modality therapy on neoadjuvant Cooperative Osteosarcoma Study Group protocols(More)
OBJECTIVE To analyze prospectively the impact of age at diagnosis in childhood idiopathic thrombocytopenic purpura (ITP). STUDY DESIGN International registry from June 1997 to May 2001, with analysis of data from baseline and 6-month-follow-up questionnaires. RESULTS Data from 2540 patients were analyzed, including 203 infants (7.6%), 1860 children > or(More)
BACKGROUND The standard treatment of fever in chemotherapy-induced neutropenia (FN) includes emergency hospitalization and empirical intravenous antimicrobial therapy. This study determined if first-day step-down to oral outpatient treatment is not inferior to continued standard regarding safety and efficacy in children with low-risk FN. PROCEDURE In a(More)