Thomas Joseph Matthews

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Enfuvirtide (ENF), the first approved fusion inhibitor (FI) for HIV, is a 36-aa peptide that acts by binding to the heptad repeat 1 (HR1) region of gp41 and preventing the interaction of the HR1 and HR2 domains, which is required for virus-cell fusion. Treatment-acquired resistance to ENF highlights the need to create FI therapeutics with activity against(More)
Conservation Biogeography and Macroecology Programme, School of Geography and the Environment, University of Oxford, South Parks Road, Oxford, OX1 3QY, UK, CE3C – Centre for Ecology, Evolution and Environmental Changes / Azorean Biodiversity Group and Universidade dos Ac ores Departamento de Cîencias Agr arias, 9700-042, Angra do Hero ısmo, Ac ores,(More)
The distribution and localization of a glioma-associated antigen defined by monoclonal antibody 81C6 has been examined using human cultured cell lines and tissues. Monoclonal antibody 81C6 was selected from a hybridoma fusion of spleen cells of mice immunized with the glial fibrillary acidic protein-positive human glioma cell line U-251 MG. Results of cell(More)
Artificial lighting is strongly associated with urbanisation and is increasing in its extent, brightness and spectral range. Changes in urban lighting have both positive and negative effects on city performance, yet little is known about how its character and magnitude vary across the urban landscape. A major barrier to related research, planning and(More)
Conservation Biogeography and Macroecology Programme, School of Geography and the Environment, University of Oxford, South Parks Road, Oxford OX1 3QY, UK, CE3C – Centre for Ecology, Evolution and Environmental Changes / Azorean Biodiversity Group and Universidade dos Açores – Departamento de Ciências Agrárias, 9700-042, Angra do Heroísmo, Açores, Portugal,(More)
Conservation Biogeography and Macroecology Programme, School of Geography and the Environment, University of Oxford, Oxford OX1 3QY, UK, Departamento de Cîencias Agr arias – CITAA, Azorean Biodiversity Group, Universidade dos Ac ores, Angra do Hero ısmo, Pico da Urze, 9700-042 Terceira, Ac ores, Portugal, Department of Biogeography, BayCEER, University of(More)
To study HIV-1 primary isolate neutralization, we have used DH012 as a model to study the immunogenicity of several DH012 immunogens and determine the potential neutralization epitopes in the virus envelope glycoprotein. Previously, we identified that DH012 infected animals mount potent neutralizing activity against a conformational epitope (CEV) that(More)
As the global population urbanizes, dramatic changes are expected in city lighting and the urban form, which may threaten the functioning of urban ecosystems and the services they deliver. However, little is known about the ecological impact of lighting in different urban contexts. Movement is an important ecological process that can be disrupted by(More)
Thomas J. Matthews* and Robert J. Whittaker Conservation Biogeography and Macroecology Group, School of Geography and the Environment, University of Oxford, South Parks Road, Oxford OX1 3QY, UK; Azorean Biodiversity Group (ABG, CITA-A) and Portuguese Platform for Enhancing Ecological Research & Sustainability (PEERS), Departamento de Ciências Agr arias,(More)
School of Geography and the Environment, OUCE, University of Oxford, South Parks Road, Oxford OX1 3QY, UK, CE3C – Centre for Ecology, Evolution and Environmental Changes / Azorean Biodiversity Group and Universidade dos Açores, Departamento de Ciências Agrárias, 9700-042, Angra do Heroísmo, Açores, Portugal, Center for Macroecology, Evolution and Climate,(More)