The investigation of interleukin 1beta (IL-1beta) in human inflammatory diseases is hampered by the fact that it is virtually undetectable in human plasma. We demonstrate that by administering the anti-human IL-1beta antibody canakinumab (ACZ885) to humans, the resulting formation of IL-1beta-antibody complexes allowed the detection of in vivo-produced… (More)
INTRODUCTION IL-1beta is a proinflammatory cytokine driving joint inflammation as well as systemic signs of inflammation, such as fever and acute phase protein production. METHODS ACZ885, a fully human monoclonal antibody that neutralizes the bioactivity of human IL-1beta, was generated to study the potent and long-lasting neutralization of IL-1beta in… (More)
INTRODUCTION Cryopyrin-associated periodic syndrome (CAPS) represents a spectrum of three auto-inflammatory syndromes, familial cold auto-inflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease/chronic infantile neurological cutaneous and articular syndrome (NOMID/CINCA) with etiology linked to… (More)
Directly modulated fiber-optic links offers significant advantages in system cost and complexity. However, they often suffer from high link loss and inferior RF performance compared with externally modulated links. In this paper, we have experimentally investigated tbe amplitude modulation (AM) elfieiency, modulation bandwidth, and the nonlinear distortions… (More)
—We report on a novel monolithic distributed traveling wave photodetector with parallel optical feed to an array of individual photodiodes using an integrated multimode interference (MMI) coupler to attain high saturation current. The parallel optical feed reduces the maximum photocurrent and photocurrent density seen by any single photodiode, thus… (More)
—A coherent optical RF channelizer has been constructed and characterized. The optical channelizer is based on a free-space optical diffraction grating, and utilizes coherent optical heterodyne detection to translate all of the frequency channels to a common intermediate frequency (IF). The designed optical channelizer has a 1-GHz channel spacing, and a… (More)
We report on the experimental demonstration of directly modulated analog fiber optic links with gain-coupled DFB lasers under strong optical injection locking. Successful transmission of BPSK signals up to 18 GHz has been achieved.
AbnroccWe hsvr experimen11IIy invedigalcd the dynamic pcrformnnrr and the rvppreuion of non-linear distortioos of a mooolithir optical injection-lmkd d i d h u t e d Lcdhnek (DFB) Inrcr.
The base attitude of a free floating space robot may change while performing a motion with its manipulator. This dynamic coupling complicates the motion planning of the space robot and must be taken into account in order to reach a target point with a desired end-effector pose. However, the free floating mode is useful, because of its energy efficiency, and… (More)