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Reactive oxygen species (ROS) and signaling events are involved in the pathogenesis of endothelial dysfunction and represent a major contribution to vascular regulation. Molecular signaling is highly dependent on ROS. But depending on the amount of ROS production it might have toxic or protective effects. Despite a large number of negative outcomes in large(More)
Our previous studies identified potent antioxidant effects and improvement of vascular function by telmisartan therapy in experimental diabetes and nitrate tolerance. The present study compared the beneficial effects of single telmisartan or amlodipine versus telmisartan/amlodipine combination therapy (T+A) in streptozotocin (STZ)-induced type 1 diabetic(More)
The Fourier volume rendering technique operates in the frequency domain and creates line integral projections of a 3D scalar field. These projections can be efficiently generated in) log O(2 N N time by utilizing the Fourier Slice-Projection theorem. However, until now, the mathematical difficulty of the Fast Fourier Transform prevented acceleration by(More)
We introduce a novel span-triangle data structure, based on the span-space representation for isosurfaces. It stores all necessary cell information for dynamic manipulation of the isovalue in an efficient way. We have found that using our data structure in combination with point-based techniques, implemented on graphics hardware, effects in real-time(More)
This paper introduces an extendable cross-platform software framework Julius for medical visualization and surgical planning, consisting of two conceptual layers: the Julius Software Development Kit (JSDK) and the Julius Graphical User Interface (JGUI). The JSDK can be used stand-alone to speed up development of research tools. While the JGUI acts like a(More)
Organic nitrates are a group of very effective anti-ischemic drugs. They are used for the treatment of patients with stable angina, acute myocardial infarction and chronic congestive heart failure. A major therapeutic limitation inherent to organic nitrates is the development of tolerance, which occurs during chronic treatment with these agents. The(More)
BACKGROUND Linear scleroderma "en coup de sabre" (LSCS) usually affects one side of the face and head in the frontoparietal area with band-like indurated skin lesions. The disease may be associated with facial hemiatrophy. Various ophthalmological and neurological abnormalities have been observed in patients with LSCS. We describe an unusual case of LSC. (More)
OBJECTIVE In diabetes, vascular dysfunction is characterized by impaired endothelial function due to increased oxidative stress. Empagliflozin, as a selective sodium-glucose co-transporter 2 inhibitor (SGLT2i), offers a novel approach for the treatment of type 2 diabetes by enhancing urinary glucose excretion. The aim of the present study was to test(More)
In this paper we introduce the extendable cross-platform software framework Julius for medical visualization and surgical planning, consisting of two conceptual layers: the Julius Software Development Kit (JSDK) and its frontend the Julius Graphical User Interface (JGUI). Julius features a modular, platform-independent design and includes a full set of(More)