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Vitamin D Deficiency and Risk of Cardiovascular Disease
TLDR
Vitamin D deficiency is associated with incident cardiovascular disease and further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease.
Genome-wide association study of blood pressure and hypertension
TLDR
A genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium identifies 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10−7.
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
TLDR
Variants near genes involved in cholesterol synthesis, hydroxylation, and vitamin D transport affect vitamin D status, and genetic variation at these loci identifies individuals who have substantially raised risk of vitamin D insufficiency.
Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study
TLDR
Lifetime risks for development of AF are 1 in 4 for men and women 40 years of age and older, even in the absence of antecedent congestive heart failure or myocardial infarction, and substantial lifetime risks underscore the major public health burden posed by AF.
Metabolite profiles and the risk of developing diabetes
TLDR
Findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment.
Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease
TLDR
FGF-23 is independently associated withleft ventricular mass index and left ventricular hypertrophy in patients with CKD, and whether increased FGF- 23 is a marker or a potential mechanism of myocardial hyperTrophy in CKD requires further study.
Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on Mortality The Framingham Heart Study
TLDR
Individuals with AF or CHF who subsequently develop the other condition have a poor prognosis, and additional studies addressing the pathogenesis, prevention, and optimal management of the joint occurrence of AF and CHF appear warranted.
Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study
TLDR
From clinical factors readily accessible in primary care, the risk score could help to identify risk of atrial fibrillation for individuals in the community, assess technologies or markers for improvement of risk prediction, and target high-risk individuals for preventive measures.
Multiple biomarkers for the prediction of first major cardiovascular events and death.
TLDR
The use of the 10 contemporary biomarkers that were studied adds only moderately to standard risk factors and only small increases in the ability to classify risk, as measured by the C statistic.
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
TLDR
A mass spectrometry‐based strategy to simultaneously measure 191 metabolites following glucose ingestion laid the groundwork for using metabolic profiling to define an individual's ‘insulin response profile’, which could have value in predicting diabetes, its complications, and in guiding therapy.
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