Metabolite profiles and the risk of developing diabetes
Findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment.
Vitamin D Deficiency and Risk of Cardiovascular Disease
Vitamin D deficiency is associated with incident cardiovascular disease and further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease.
Genome-wide association study of blood pressure and hypertension
A genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium identifies 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10−7.
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on Mortality The Framingham Heart Study
Individuals with AF or CHF who subsequently develop the other condition have a poor prognosis, and additional studies addressing the pathogenesis, prevention, and optimal management of the joint occurrence of AF and CHF appear warranted.
Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study
Lifetime risks for development of AF are 1 in 4 for men and women 40 years of age and older, even in the absence of antecedent congestive heart failure or myocardial infarction, and substantial lifetime risks underscore the major public health burden posed by AF.
The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective
Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study
Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk
A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training
This study examined plasma profiles of specific c‐miRNAs in healthy competitive athletes at rest and during exhaustive exercise testing, before and after a 90 day period of exercise training, to set the stage for further work aimed at defining the role of c‐ miRNAs as fitness biomarkers and physiological mediators of exercise‐induced cardiovascular adaptation.