Thomas J. Ow

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Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is recognized as a distinct disease entity associated with improved survival. DNA hypermethylation profiles differ significantly by HPV status suggesting that a specific subset of methylated CpG loci could give mechanistic insight into HPV-driven OPSCC. We analyzed genome-wide(More)
The oral cavity is the most common site of head and neck squamous cell carcinoma, a disease which results in significant morbidity and mortality worldwide. Though the primary modality of treatment for patients with oral cavity cancer remains surgical resection, many patients present with advanced disease and are thus treated using a multi-disciplinary(More)
BACKGROUND AND PURPOSE Criteria for detection of persistent nodal metastases in treated oropharyngeal tumors are sensitive but nonspecific, leading to unnecessary nodal dissections. Developing specific imaging criteria for persistent nodal metastases could improve diagnosis while decreasing patient morbidity. MATERIALS AND METHODS Patients with(More)
We previously reported a novel association between CDKN2A nonpromoter methylation and transcription (ARF/INK4a) in human papillomavirus associated oropharyngeal tumors. In this study we assessed whether nonpromoter CDKN2A methylation in laryngeal squamous cell carcinomas (LXSCC) conferred a similar association with transcription that predicted patient(More)
The spliceosome is a large and complex ribonucleic protein (RNP) that consist of 5 small nuclear RNPs (snRNPs): U1, U2, U4, U5 and U6 that base pair with and recognize splice site sequences in pre-mRNA. The spliceosome is the molecular machinery responsible for the two subsequent transesterification reactions that remove intronic regions of RNA and join the(More)
It is estimated that 1.4 million New York City residents rely on food pantries and soup kitchens to feed themselves and their families. With a growing population of homeless individuals in urban America, emergency food programs have struggled to satisfy the needs of this food insecure population. Studies have suggested that emergency food programs often(More)
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