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BACKGROUND Effective palliation rather than cure is often the most appropriate goal in the management of patients with advanced gastric cancer. The literature to date is limited by the imprecise use of the term palliative and subsequent variable designation of patients into evaluable groups. STUDY DESIGN Between July 1985 and July 2001, 1,595 patients(More)
OBJECTIVE To prospectively evaluate surgical procedures performed with palliative intent. SUMMARY BACKGROUND DATA There is a paucity of outcomes data necessary to allow sound surgical decision-making and informed consent for palliative procedures. METHODS Procedures to palliate symptoms of advanced cancer were identified prospectively from all(More)
SUMMARY BACKGROUND DATA Pseudomyxoma peritonei (PMP) is a clinical syndrome with a poorly defined natural history. Relative contributions of tumor biology, patient selection, and the extent of treatment on ultimate outcome are not well characterized. METHODS Patients treated at the Memorial Sloan-Kettering Cancer Center between 1980 and 2002 with a(More)
Primary vaginal melanoma is a rare and highly malignant disease. The impact of therapy on outcomes is poorly understood. Records of all patients treated for primary vaginal melanoma at Memorial Sloan-Kettering Cancer Center from 1977 to 2001 were reviewed. Survival analysis was performed based on appropriate patient, tumor, and treatment variables.(More)
Surgery is currently the only potentially curative treatment for gastric cancer. Since the inception of the gastrectomy for cancer of the stomach, there has been debate over the bounds of surgical therapy, balancing potential long-term survival with perioperative morbidity and mortality. This review delineates the current role of surgery in preoperative(More)
OBJECTIVE For patients with laparoscopic stage M1 gastric adenocarcinoma, no resection of the primary tumor, and systemic chemotherapy, this study investigated the incidence of subsequent palliative intervention and survival. SUMMARY BACKGROUND DATA Laparoscopy was performed for patients with computed tomography scan stage M0 disease and no significant(More)
Malignant ascites indicates the presence of malignant cells in the peritoneal cavity and is a grave prognostic sign. While survival in this patient population is poor, averaging about 20 wk from time of diagnosis, quality of life can be improved through palliative procedures. Selecting the appropriate treatment modality remains a careful process, which(More)
Nitric Oxide's (NO) function in vasomotor control, inflammation, and signal transduction makes it an attractive potential mediator of the capillary leak seen in acute lung injury. Despite extensive study, the role of NO in intestinal ischemia/reperfusion-induced capillary leak remains controversial. Rats were treated with vehicle, norepinephrine, or L-NNA(More)
4048 Background: Lenalidomide is an immunomodulatory and anti-angiogenic agent that appears to inhibit endothelial cell signaling induced by vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). FGF is an important growth factor in HCC. There is no standard of care for patients who progress on sorafenib. Therefore, we performed a(More)
INTRODUCTION When considering the appropriate and effective use of palliative procedures, a surgeon is often confronted with a full range of multidisciplinary treatment options and technical considerations that could potentially relieve some of the symptoms of an advanced malignancy. Practitioners must often deliberate over complex choices that can greatly(More)