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Pathway Tools is a production-quality software environment for creating a type of model-organism database called a Pathway/Genome Database (PGDB). A PGDB such as EcoCyc integrates the evolving understanding of the genes, proteins, metabolic network and regulatory network of an organism. This article provides an overview of Pathway Tools capabilities. The(More)
BACKGROUND This article addresses the problem of interoperation of heterogeneous bioinformatics databases. RESULTS We introduce BioWarehouse, an open source toolkit for constructing bioinformatics database warehouses using the MySQL and Oracle relational database managers. BioWarehouse integrates its component databases into a common representational(More)
We describe a novel approach for predicting the function of a protein from its amino-acid sequence. Given features that can be computed from the amino-acid sequence in a straightforward fashion (such as pI, molecular weight, and amino-acid composition), the technique allows us to answer questions such as: Is the protein an enzyme? If so, in which Enzyme(More)
We describe a plan-authoring system called PASSAT (Plan-Authoring System based on Sketches, Advice, and Templates) that combines interactive tools for constructing plans with a suite of automated and mixed-initiative capabilities designed to complement human planning skills. PASSAT is organized around a library of predefined templates that encode task(More)
INTRODUCTION We compared esophageal acid exposure data obtained during simultaneous esophageal pH studies using the Bravo wireless and the Slimline catheter-Mark III Digitrapper pH systems. METHODS Twenty-five asymptomatic subjects underwent endoscopy with endoclip placement at the squamocolumnar junction (SCJ) and manometry to localize the lower(More)
In a recent paper, Friedman, Geiger, and Goldszmidt [8] introduced a classifier based on Bayesian networks, called Tree Augmented Naive Bayes (TAN), that outperforms naive Bayes and performs competitively with C4.5 and other state-of-the-art methods. This classifier has several advantages including robustness and polynomial computational complexity. One(More)
There is an increasing need for automated support for humans monitoring the activity of distributed teams of cooperating agents, both human and machine. We characterize the domain-independent challenges posed by this problem, and describe how properties of domains influence the challenges and their solutions. We will concentrate on dynamic, data-rich(More)
BACKGROUND Access to essential maternal and reproductive health care is poor throughout Burma, but is particularly lacking among internally displaced communities in the eastern border regions. In such settings, innovative strategies for accessing vulnerable populations and delivering basic public health interventions are urgently needed. METHODS Four(More)