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  • Romain Zufferey, John E. Donello, Didier Trono, Thomas J Hope
  • Biology, Medicine
  • Journal of virology
  • 1999 (First Publication: 1 April 1999)
  • The expression of genes delivered by retroviral vectors is often inefficient, a potential obstacle for their widespread use in human gene therapy. Here, we explored the possibility that theContinue Reading
  • Jayne M. Stommel, Natalia D. Marchenko, Gretchen S. Jimenez, Ute M. Moll, Thomas J Hope, Geoffrey M. Wahl
  • Biology, Medicine
  • The EMBO journal
  • 1999 (First Publication: 15 March 1999)
  • Appropriate subcellular localization is crucial for regulating p53 function. We show that p53 export is mediated by a highly conserved leucine-rich nuclear export signal (NES) located in itsContinue Reading
  • Philippe A Gallay, Thomas J Hope, David Chin, Didier Trono
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 1997 (First Publication: 2 September 1997)
  • The karyophilic properties of the HIV-1 nucleoprotein complex facilitate infection of nondividing cells such as macrophages and quiescent T lymphocytes, and allow the in vivo delivery of transgenesContinue Reading
  • Xiaolu Wu, Jenny L Anderson, Edward M Campbell, Ajith M. Joseph, Thomas J Hope
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2006 (First Publication: 9 May 2006)
  • The primate TRIM5alpha proteins have recently been defined as cellular restriction factors, preventing primate infection by retroviruses from different species. For instance, rhesus TRIM5alphaContinue Reading