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- T J Hagenaars, C A Donnelly, N M Ferguson
- Journal of theoretical biology
- 2004

The endemic persistence of infectious diseases can often not be understood without taking into account the relevant heterogeneities of host mixing. Here, we consider spatial heterogeneity, defined as 'patchiness' of the host population. After briefly reviewing how disease persistence is influenced by population size, reproduction number and infectious… (More)

- A C Ghani, N M Ferguson, C A Donnelly, T J Hagenaars, R M Anderson
- Proceedings. Biological sciences
- 1998

Understanding the epidemiology and aetiology of new-variant Creutzfeldt-Jakob (vCJD) disease in humans has become increasingly important given the scientific evidence linking it to bovine spongiform encephalopathy (BSE) in cattle and hence the wide exposure of the population of Great Britain (GB) to potentially infectious tissue. The recent analysis… (More)

- Gert Jan Boender, Thomas J. Hagenaars, +4 authors Michiel van Boven
- PLoS Computational Biology
- 2007

Devastating epidemics of highly contagious animal diseases such as avian influenza, classical swine fever, and foot-and-mouth disease underline the need for improved understanding of the factors promoting the spread of these pathogens. Here the authors present a spatial analysis of the between-farm transmission of a highly pathogenic H7N7 avian influenza… (More)

- Sido D Mylius, Thomas J Hagenaars, Anna K Lugnér, Jacco Wallinga
- Vaccine
- 2008

The limited production capacity for vaccines raises the question what the best strategy is for allocating the vaccine to mitigate an influenza pandemic. We developed an age-structured model for spread of an influenza pandemic and validated it against observations from the Asian flu pandemic. Two strategies were evaluated: vaccination can be implemented at… (More)

- N M Ferguson, A C Ghani, C A Donnelly, T J Hagenaars, R M Anderson
- Nature
- 2002

Following the controversial failure of a recent study and the small numbers of animals yet screened for infection, it remains uncertain whether bovine spongiform encephalopathy (BSE) was transmitted to sheep in the past via feed supplements and whether it is still present. Well grounded mathematical and statistical models are therefore essential to… (More)

- R N Zadoks, H G Allore, T J Hagenaars, H W Barkema, Y H Schukken
- Epidemiology and infection
- 2002

An ordinary differential equation model was developed to simulate dynamics of Staphylococcus aureus mastitis. Data to estimate model parameters were obtained from an 18-month observational study in three commercial dairy herds. A deterministic simulation model was constructed to estimate values of the basic (R0) and effective (Rt) reproductive number in… (More)

- T J Hagenaars, N M Ferguson, C A Donnelly, A C Ghani, R M Anderson
- Proceedings. Biological sciences
- 2000

An unresolved issue in the epidemiology of bovine spongiform encephalopathy (BSE) in the UK is what precisely determines the degree to which cases of disease in cattle are clustered within herds throughout the course of the epidemic. This paper presents an analysis of feed-borne transmission at the herd level and tests various models of case-clustering… (More)

- T J Hagenaars, C A Donnelly, N M Ferguson, R M Anderson
- Mathematical biosciences
- 2000

We formulate and investigate the properties of a model framework to mimic the transmission dynamics of the aetiological agent of scrapie in a sheep flock. We derive expressions for summary parameters that characterize transmission scenarios, notably the basic reproduction number R(0) and the mean generation time T(g). The timescale of epidemic outbreaks is… (More)

- T J Hagenaars, C A Donnelly, N M Ferguson
- Epidemiology and infection
- 2006

In recent years, the control or eradication of scrapie and any other transmissible spongiform encephalopathies (TSEs) possibly circulating in the sheep population has become a priority in Britain and elsewhere in Europe. A better understanding of the epidemiology of scrapie would greatly aid the development and evaluation of control and eradication… (More)

- T J Hagenaars, C A Donnelly, N M Ferguson, R M Anderson
- Epidemiology and infection
- 2003

Knowledge of epidemiological mechanisms and parameters underlying scrapie transmission in sheep flocks remains very limited at present. Here we introduce a method for fitting stochastic transmission models to outbreak data to estimate bounds on key transmission parameters. We apply this method to data describing an outbreak of scrapie in a closed flock of… (More)