Thomas J. Farrell

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Diffuse optical methods were used to monitor two different therapies in K1735 malignant mouse melanoma tumor models: anti-vascular therapy and radiation therapy. Anti-vascular therapy induced acute variation in hemodynamic parameters within an hour, and radiation therapy induced longitudinal changes within 2 weeks. During anti-vascular therapy, the drug(More)
Three-dimensional (3-D) models of light propagation in diffuse optical tomography provide an accurate representation of scattering in tissue. Here the use of spectral priors, shown to improve quantification of functional parameters in 2-D, has been extended to 3-D. To make 3-D spectral imaging computationally tractable, a novel technique is presented to(More)
Optical imaging of fluorescent objects embedded in a tissue simulating medium was characterized using non-contact based approaches to fluorescence remittance imaging (FRI) and sub-surface fluorescence diffuse optical tomography (FDOT). Using Protoporphyrin IX as a fluorescent agent, experiments were performed on tissue phantoms comprised of typical in-vivo(More)
The 2dF (Two-degree Field) facility at the prime focus of the Anglo-Australian Telescope provides multiple object spectroscopy over a 2 • field of view. Up to 400 target fibres can be independently positioned by a complex robot. Two spectrographs provide spectra with resolutions of between 500 and 2000, over wavelength ranges of 440nm and 110nm(More)
The performance of a simple approach for the in vivo reconstruction of bioluminescent point sources in small animals was evaluated. The method uses the diffusion approximation as a forward model of light propagation from a point source in a homogeneous tissue to find the source depth and power. The optical properties of the tissue are estimated from(More)
The efficacy of chemotherapy is related, in large part, to the concentration of drug that reaches tumor sites. Doxorubicin (DOX) is a common anti-cancer drug that is also approved for use in liposomal form for the treatment of ovarian cancer. We recently developed a porphyrin-phospholipid (PoP)-liposome system that enables on demand release of DOX from(More)
The AAO's new AAO2 detector controllers can handle both infra-red detectors and optical CCDs. IR detectors in particular place considerable demands on a data handling system, which has to get the data from the controllers into the data processing chain as efficiently as possible, usually with significant constraints imposed by the need to read out the(More)
We have performed differential display comparing gene expression from cell lines derived from human colorectal tumors. The cell lines were selected for study based on their ability to form metastases following injection into athymic mice. One gene which was expressed exclusively by the metastatic lines was identified as human acylphosphatase (e.c. 3.6.1.7,(More)
  • F G Watson, Q A Parker, G Bogatu, T J Farrell, B E Hingley, S Miziarski
  • 2007
6dF (for 6-degree eld) is a fully-automated front-end for the multi-object bre-coupled spectroscopy system of the UK Schmidt Telescope (UKST). It is a magnetic pick-place system with an (r;) positioning robot, and it will replace the manually-conngured FLAIR front-end that has been operated on the telescope in its present form since 1992. The one-hour(More)
The fluorescence of Intralipid and polystyrene microspheres with sphere diameter of 1 µm at a representative lipid and microsphere concentration for simulation of mucosal tissue scattering has not been a subject of extensive experimental study. In order to elucidate the quantitative relationship between lipid and microsphere concentration and the respective(More)