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BACKGROUND Trials of statin therapy have had conflicting findings on the risk of development of diabetes mellitus in patients given statins. We aimed to establish by a meta-analysis of published and unpublished data whether any relation exists between statin use and development of diabetes. METHODS We searched Medline, Embase, and the Cochrane Central(More)
BACKGROUND The effects of cholesterol-lowering treatment with statins on mortality and risk of cancer beyond the usual 5-6-year trial periods are unknown. We extended post-trial follow-up of participants in the Scandinavian Simvastatin Survival Study (4S) to investigate cause-specific mortality and incidence of cancer 5 years after closure of the trial. (More)
The efficacy of chemotherapy of lung cancer is limited by the development of resistance in cancer cells during treatment. In most lung cancers, this resistance is associated with the overexpression of (a) multidrug resistance-associated protein (MRP) responsible for drug efflux from the cancer cells (pump resistance) and (b) BCL2 protein that activates(More)
In this paper we solve two biharmonic problems over a square, B = (−1, 1) × (−1, 1). (1) The problem ∇ 4 U = f , for which we determine a particular solution, U , given f , via use of Sinc convolution; and (2) The boundary value problem ∇ 4 V = 0 for which we determine V given V = g and normal derivative Vn = h on ∂B, the boundary of B. The solution to this(More)
A dynamic address computation mechanism for use in database management is presented. The address computation technique allows information structured according to a given pre-defined tree to be stored without any address pointers, yet the populated tree is assumed to have an arbitrary number of branches below non-terminating tree nodes, and have arbitrary(More)
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