BACKGROUND Trials of statin therapy have had conflicting findings on the risk of development of diabetes mellitus in patients given statins. We aimed to establish by a meta-analysis of published and unpublished data whether any relation exists between statin use and development of diabetes. METHODS We searched Medline, Embase, and the Cochrane Central… (More)
BACKGROUND The effects of cholesterol-lowering treatment with statins on mortality and risk of cancer beyond the usual 5-6-year trial periods are unknown. We extended post-trial follow-up of participants in the Scandinavian Simvastatin Survival Study (4S) to investigate cause-specific mortality and incidence of cancer 5 years after closure of the trial. … (More)
A review of the development and implementation of a 4-year medical student integrated ultrasound curriculum is presented. Multiple teaching and assessment modalities are discussed as well as results from testing and student surveys. Lessons learned while establishing the curriculum are summarized. It is concluded that ultrasound is a well received, valuable… (More)
Published databases of quantitative sensory testing (QST) for sensory thresholds provide a means for detecting deficits of the thermonociceptive sensory nervous system. These databases, however, do not assist in the assessment of neuropathic pain, which is characterized by pain or hyperalgesia, or both. We utilized the method of levels for innocuous thermal… (More)
The efficacy of chemotherapy of lung cancer is limited by the development of resistance in cancer cells during treatment. In most lung cancers, this resistance is associated with the overexpression of (a) multidrug resistance-associated protein (MRP) responsible for drug efflux from the cancer cells (pump resistance) and (b) BCL2 protein that activates… (More)
The separation of all representations of structural properties from data is proposed as a stratagem for data base management system (DBMS) design. The DBMS operates by creating for each user an interpreted user-oriented data base machine which utilizes the separated structure representations as an instruction stream. An example of the user data base machine… (More)
In this paper we solve two biharmonic problems over a square, B = (−1, 1) × (−1, 1). (1) The problem ∇ 4 U = f , for which we determine a particular solution, U , given f , via use of Sinc convolution; and (2) The boundary value problem ∇ 4 V = 0 for which we determine V given V = g and normal derivative Vn = h on ∂B, the boundary of B. The solution to this… (More)
¿Qué lecciones aprendimo nuevamente) del asesoram del 11-S?