Thomas Huebner

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Limitation of infarct size is a major goal of therapy for acute coronary syndromes, and research has focused on achieving rapid patency of infarct-related vessels. However, new understandings of epigenetic modifications during ischemia suggest additional targeted approaches that have not been extensively explored. Here, we show that ischemia induces histone(More)
The objective of this study was to develop an automatic signal analysis system for heart sound diagnosis. This should support the general practitioner in discovering aortic valve stenoses at an early stage to avoid or decrease the number of surgical interventions. The applied analysis method is based on classification of heart sound signals utilising(More)
This study has aimed to develop a novel pre-diagnostic tool for primary care screening of heart disease based on multivariate short-term heart rate variability (HRV) analyzed by linear (time and frequency domain) and nonlinear methods (compression entropy (CE), detrended fluctuation analysis (DFA), Poincaré plot analysis, symbolic dynamics) applied to 5-min(More)
Oxidative stress is one major factor in upper aerodigestive tract carcinogenesis. Reactive oxygen species derived from environmental sources, cigarette smoke or cellular metabolism, constantly attack large molecules within the cell. While damaged lipids and proteins can be replaced, oxidative DNA damage needs to be repaired. Damage exceeding DNA repair(More)
BACKGROUND Electrocardiographic methods still provide the bulk of cardiovascular diagnostics. Cardiac ischemia is associated with typical alterations in cardiac biosignals that have to be measured, analyzed by mathematical algorithms and allegorized for further clinical diagnostics. The fast growing fields of biomedical engineering and applied sciences are(More)
Traditional auscultation performed by the general practitioner remains problematic and often gives significant results only in a late stage of heart valve disease. Valve stenoses and insufficiencies are nowadays diagnosed with accurate but expensive ultrasonic devices. This studyaimed to develop a new heart sound analysis method for diagnosing aortic valve(More)
Cardiogoniometry (CGM), a spatiotemporal electrocardiologic 5-lead method with automated analysis, may be useful in primary healthcare for detecting coronary artery disease (CAD) at rest. Our aim was to systematically develop a stenosis-specific parameter set for global CAD detection. In 793 consecutively admitted patients with presumed non-acute CAD, CGM(More)
INTRODUCTION This study investigates the accuracy of a heart rate (HR) measurement algorithm applied to a pulse wave. This was based on video signals recorded with a smartphone. The results of electrocardiographic HR and standard linear heart rate variability (HRV) analysis were used for reference. MATERIALS AND METHODS On a total of 68 subjects, an(More)
Aims Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice, and its paroxysmal nature makes its detection challenging. In this trial, we evaluated a novel App for its accuracy to differentiate between patients in AF and patients in sinus rhythm (SR) using the plethysmographic sensor of an iPhone 4S and the integrated LED(More)
BACKGROUND Cardiogoniometry (CGM) is a novel resting electrocardiac method based on computer-generated three-dimensional data derived from cardiac potentials. The purpose of this study was to determine CGM's and electrocardiography's (ECG) accuracy for detecting myocardial ischemia and/or lesions in comparison with stress/rest myocardial perfusion(More)