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PURPOSE We assessed the impact of visual impairment on the incidence of falls and fractures in older persons. METHODS Of 3654 baseline participants, 2334, 1952, and 1149 were re-examined after 5, 10, and 15 years. Presenting visual acuity (VA) was measured at each examination. Bilateral and unilateral visual impairment was defined as VA worse than 20/40(More)
Organophosphate compounds, which are widely used as pesticides and chemical warfare agents, are cholinesterase inhibitors. These synthetic compounds are resistant to natural degradation and threaten the environment. We constructed a strain of Pseudomonas putida that can efficiently degrade a model organophosphate, paraoxon, and use it as a carbon, energy,(More)
PURPOSE Previous studies have reported high right-left eye correlation in retinal vessel caliber. We test the hypothesis that right-left correlation in retinal vessel caliber would be reduced in anisometropic compared with emmetropic children. METHODS Retinal arteriolar and venular calibers were measured in 12-year-old children. Three groups were(More)
The presence of visual impairment (VI) and hearing loss (HL) with may be a marker for subsequent cognitive decline over time in older people. A prospective, longitudinal population-based study of the 3654 participants of the Blue Mountains Eye Study were assessed for the associations between VI and HL and a decline in mini-mental state examination (MMSE)(More)
PURPOSE To systematically review anatomical and functional outcomes subsequent to switching from bevacizumab/ranibizumab to aflibercept monotherapy in patients with treatment-resistant neovascular age-related macular degeneration (nAMD). DESIGN Systematic review and meta-analysis. METHODS Medline, PubMed, Embase, and Cochrane databases were searched up(More)
Diabetic macular edema (DME) represents one of the leading causes of visual impairment in working-age adults. Although there are several proven treatments available for this condition, pharmacotherapy through the use of intravitreal antivascular endothelial growth factor agents has revolutionized the management of DME over the past decade with superior(More)
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