Thomas Holm

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Reactive gliosis is a prominent feature of neurodegenerative and neuroinflammatory disease in the CNS, yet the stimuli that drive this response are not known. There is growing appreciation that signaling through Toll-like receptors (TLRs), which is key to generating innate responses to infection, may have pathogen-independent roles. We show that TLR2 was(More)
Cataract is the leading cause of blindness, especially in the developing world. To ease access to treatment, we have proposed that cataract could be treated non-invasively by photobleaching of the chemically modified proteins responsible for cataract formation. The present study was aimed at examining the optical and biochemical effects of the proposed(More)
BACKGROUND Glutathione concentration in the lens decreases in aging and cataractous lenses, providing a marker for tissue condition. Experimental procedures requiring unfrozen lenses from donor banks rely on transportation in storage medium, affecting lens homeostasis and alterations in glutathione levels. The aim of the study was to examine the effects of(More)
Abstrakt: Dieser Beitrag stellt das Vorgehen und die genutzten Modelle bei der Erstellung von Automatisierungssoftware beim Engineering automatisierter Anla-gen dar. Darauf aufbauend wird die Idee, welche der Kontextmodellierung im all-gemeinen Software-Engineering zu Grunde liegt, auf Anwendbarkeit innerhalb der Automatisierungstechnik geprüft. Daraus(More)
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