Thomas Hilger

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Active Bacterial Core surveillance (ABCs) is a collaboration between the Centers for Disease Control and Prevention and several state health departments and universities participating in the Emerging Infections Program Network. ABCs conducts population-based active surveillance, collects isolates, and performs studies of invasive disease caused by(More)
We measured reflectance changes by means of optical imaging of intrinsic signals to study the effects of acute electrical cochlear stimulation on the topography of the cat auditory cortex. After single-pulse electrical stimulation at selected sites of a multichannel implant device, we found topographically restricted response areas representing mainly the(More)
We measured reflectance changes by means of optical imaging of intrinsic signals to study the topography of the paw representations in rat somatosensory cortex. Following circumscribed tactile stimulation of single digits or pads, we found large and partially overlapping areas of reflectance changes (delta R). The diameters of their focal zones defined at(More)
We studied phenomena, constraints, rules, and implications of cortical plastic reorganization produced by input coactivation patterns in primary somatosensory cortex of adult rats. Intracortical microstimulation (ICMS) and an associative pairing of tactile stimulation (PPTS) induced plastic changes within minutes to hours that were fully reversible.(More)
Competition for nutrients and water between crops and associated hedgerows reduces overall performance of contour hedgerow systems and hampers its acceptance by rural communities in tropical mountainous regions. Therefore, it is imperative to better understand competition leading to a decline in crop response close to hedges. In the highlands of North East(More)
A novel photothrombotic ring stroke model was characterized by multiparametric magnetic resonance imaging, imaging of cerebral blood flow (CBF), adenosine triphosphate (ATP), pH, and histology. Ischemia was initiated by transosseous irradiation of a predefined brain area intravenously perfused by the photosensitive dye erythrosin B in male Wistar rats. In(More)
Soil conservation approaches and agroforestry systems can play an important role in controlling erosion from tropical hillside cropping systems. Experimental testing of their potential application domain and design, however, is costly and time consuming. We, therefore, tested the ability of the Water, Nutrient and Light Capture in Agroforestry Systems(More)
Magnetic resonance angiography (MRA) was performed in a thromboembolic stroke model of the rat to characterize intracranial vessel occlusion patterns and to test its predictive power for tissue recovery after recombinant tissue plasminogen activator (rt-PA) treatment. After rt-PA-treated selective middle cerebral artery (MCA) occlusion, full recanalization(More)
BACKGROUND AND PURPOSE Thrombin-induced clots used in experimental thromboembolic stroke differ from clots forming spontaneously under clinical conditions. We investigated whether this difference influences the efficacy and outcome of thrombolytic treatment. METHODS In rats, the middle cerebral artery was occluded by intracarotid injection of fibrin-rich(More)
The aim of this study is the development of a three-dimensional multicellular spheroid cell culture model for the longitudinal comparative and large-scale screening of cancer cell proliferation with noninvasive molecular imaging techniques under controlled and quantifiable conditions. The human glioblastoma cell line Gli36ΔEGFR was genetically modified to(More)