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CD4+CD25+ regulatory T cells (T reg cells) play a key role in controlling autoimmunity and inflammation. Therefore, therapeutic agents that are capable of elevating numbers or increasing effector functions of this T cell subset are highly desirable. In a previous report we showed that a superagonistic monoclonal antibody specific for rat CD28 (JJ316)(More)
Full activation of naive T cells requires both engagement of the T cell antigen receptor (TCR; signal 1) and costimulatory signaling by CD28 (signal 2). We previously identified two types of rat CD28-specific monoclonal antibodies (mAbs): "conventional," TCR signaling-dependent costimulatory mAbs and "superagonistic" mAbs capable of inducing the full(More)
Sign language and Web 2.0 applications are currently incompatible, because of the lack of anonymisation and easy editing of online sign language contributions. This paper describes Dicta-Sign, a project aimed at developing the technologies required for making sign language-based Web contributions possible, by providing an integrated framework for sign(More)
This report describes the languages defined to interface between various components which are developed within work-package 5. At a later point of time, these languages will also become visible to other components in other work-packages as well as to users of the authoring environment. Chapter 1 gives an introduction and relates the following chapters to(More)
The paper provides a report on the user-centred showcase prototypes of the DICTA-SIGN project (http://www.dictasign.eu/), an FP7-ICT project which ended in January 2012. DICTA-SIGN researched ways to enable communication between Deaf individuals through the development of human-computer interfaces (HCI) for Deaf users, by means of Sign Language. Emphasis is(More)
Ly49 receptor genes are expressed by subsets of natural killer (NK) cells in an overlapping fashion, accounting for the capacity of NK subsets to attack host cells that have selectively downregulated self-major histocompatibility complex (MHC) class I molecules. It was shown previously that most NK cells express only one or the other allele of a given Ly49(More)
At present, fluorescence recovery after photobleaching (FRAP) data are interpreted using various types of reaction-diffusion (RD) models: the model type is usually fixed first, and corresponding model parameters are inferred subsequently. In this article, we describe what we believe to be a novel approach for RD modeling without using any assumptions of(More)