Thomas Hambrock

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This review presents the current state of the art regarding multiparametric magnetic resonance (MR) imaging of prostate cancer. Technical requirements and clinical indications for the use of multiparametric MR imaging in detection, localization, characterization, staging, biopsy guidance, and active surveillance of prostate cancer are discussed. Although(More)
In this study, computer-assisted analysis of prostate lesions was researched by combining information from two different magnetic resonance (MR) modalities: T2-weighted (T2-w) and dynamic contrast-enhanced (DCE) T1-w images. Two issues arise when incorporating T2-w images in a computer-aided diagnosis (CADx) system: T2-w values are position as well as(More)
A novel automated computerized scheme has been developed for determining a likelihood measure of malignancy for cancer suspicious regions in the prostate based on dynamic contrast-enhanced magnetic resonance imaging (MRI) (DCE-MRI) images. Our database consisted of 34 consecutive patients with histologically proven adenocarcinoma in the peripheral zone of(More)
Introduction: Prostate cancer (PCa) is currently the most frequently diagnosed non-cutaneous cancer and the second most important reason for cancer mortality in men. Early diagnosis is imperative as cure can often be established. Dynamic Contrast enhance MRI (DCE-MRI) has been established as accurate method in detection and localization of PCa. DCE-MRI is(More)
OBJECTIVES The key to MR lymphography is suppression of T2* MR signal in normal lymph nodes, while retaining high signal in metastatic nodes. Our objective is to quantitatively compare the ability of ferumoxtran-10 and ferumoxytol to suppress the MR signal in normal pelvic lymph nodes. METHODS In 2010, a set of consecutive patients who underwent(More)
Transrectal ultrasound-guided biopsy is the gold standard for prostate cancer detection. The latter detection rates of random systematic TRUS-guided biopsy do not exceed 44%. As a consequence other biopsy methods have been explored. One of these methods is MR-guided biopsy (MRGB), which revealed detection rates of 38-59% after previous negative TRUSGB(More)
CONTEXT We addressed the question whether the change of serum prostate-specific antigen (PSA) in men who use 5α-reductase inhibitor (5-ARI) dutasteride is sensitive for the detection of aggressive prostate cancer (PCa). OBJECTIVE The case of a man using dutasteride diagnosed with Gleason 7 transition zone cancer at biopsy indicated by a rising PSA is(More)
The feasibility of an automated calibration method for estimating the arterial input function when calculating pharmacokinetic parameters from Dynamic Contrast Enhanced MRI is shown. In a previous study, it was demonstrated that the computer aided diagnoses (CADx) system performs optimal when per patient calibration was used, but required manual annotation(More)
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