Thomas H. Zhou

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Prefrontal cortex (PFC) is recognized as an AD-vulnerable region responsible for defects in cognitive functioning. Pyramidal cell (PC) connections are typically facilitating (F) or depressing (D) in PFC. Excitatory post-synaptic potentials (EPSPs) were recorded using patch-clamp from single connections in PFC slices of rats and ferrets in the presence of(More)
6-Chloro n-butyl phthalide (CBP) was orally administered to healthy, male Wistar rats pretreated with or without 3-methylcholanthrene (3-MC) by a single dose of 150 mg/kg, and urine samples were collected for 0–24 h. The urine sample was hydrolyzed with β-glucuronidase, extracted and concentrated for TMS derivatization, and analysed on a GC-MS system for(More)
In this paper, the role of analytical chemistry in drug research, its development and some basic research related to developing new drugs are concisely discussed, including the establishment of quality control standards, finger prints of natural medicine products, resolution of chiral compounds and drug metabolism studies. The incorrect point of view of(More)
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