Thomas H. Smith

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To find conditions for obtaining diffraction-quality crystals of a hammerhead RNA rapidly and reproducibly, we employed a "double screening" procedure in which we screened six different RNA synthetic constructs against 48 crystallization conditions using a newly devised sparse matrix. We obtained crystals immediately and diffraction-quality crystals of the(More)
SUMMARY Malaria illness can be diagnosed by the presence of fever and parasitaemia. However, in highly endemic areas the diagnosis of clinical malaria can be difficult since children may tolerate parasites without fever and may have fever due to other causes. We propose a novel, simulation-based Bayesian approach for obtaining precise estimates of the(More)
Gallium nitride (GaN) RF power transistor and MMIC technologies have become sufficiently mature and reliable in the last few years that there are now large numbers of fielded devices in both military and commercial applications. Wide bandgap technology is now finding extended use in switching, control and low noise applications. Cree's GaN on silicon(More)
Many different methods have been proposed for the analysis of cluster randomized trials (CRTs) over the last 30 years. However, the evaluation of methods on overdispersed count data has been based mostly on the comparison of results using empiric data; i.e. when the true model parameters are not known. In this study, we assess via simulation the performance(More)
A 14-year-old female presented with common clinical findings for a rare primary intracardiac tumor. Primary cardiac tumors are rare in all age groups, occurring in 0.05% of routine postmortem examinations. Pediatric primary cardiac tumors are likewise uncommon, with the most common being a rhabdomyoma. Atrial myxomas occur infrequently in the pediatric age(More)
We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from(More)
Approved for public release; distribution is unlimited. Abstract: This report identifies rapidly colonizing and resilient grasses/forbs that are tolerant to range-relevant contaminants, with emphasis on TNT and RDX. A literature review identified herbaceous plant species with characteristics that make them potential candidates for use on ranges for(More)
Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor (GPCR) for thrombin and promotes inflammatory responses through multiple pathways including p38 mitogen-activated protein kinase signaling. The mechanisms that govern PAR1-induced p38 activation remain unclear. Here, we define an atypical ubiquitin-dependent pathway for p38 activation used(More)
The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research and development of vaccines, diagnostics and therapeutics against influenza virus by providing a(More)