Thomas H. Crook

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Cognitive decline associated with old age and consistent with the diagnosis of primary degenerative dementia is a unique clinical syndrome with characteristic phenomena and progression. The authors describe a Global Deterioration Scale for the assessment of primary degenerative dementia and delineation of its stages. The authors have used the Global(More)
Few brief self-report memory questionnaires are available, and non has been well validated. We designed a brief questionnaire, the MAC-Q, to assess age-related memory decline. Validity and reliability of the MAC-Q were assessed in 232 subjects meeting diagnostic criteria for age-associated memory impairment (AAMI). Concurrent validity of the MAC-Q was(More)
OBJECTIVES To investigate the effects of darifenacin controlled-release (CR) and oxybutynin extended-release (ER) on cognitive function (particularly memory) in older subjects. METHODS Healthy subjects (n=150) >/=60 years were randomised to darifenacin, oxybutynin ER or placebo in a multicentre, double-blind, double-dummy, parallel-group, 3-week study.(More)
A memory self-rating scale is described that includes 21 ability-to-remember items, 24 items assessing frequency of occurrence of memory failures, and 4 global rating items assessing overall comparison to others, comparison to the best one's memory has ever been, speed of recall, and concern or worry over memory function. Factor analysis yielded 5(More)
We treated 149 patients meeting criteria for age-associated memory impairment (AAMI) for 12 weeks with a formulation of phosphatidylserine (100 mg BC-PS tid) or placebo. Patients treated with the drug improved relative to those treated with placebo on performance tests related to learning and memory tasks of daily life. Analysis of clinical subgroups(More)
In general, then, the term Age-Associated Memory Impairment (AAMI) has been adopted to describe healthy persons over 50 years of age who have experienced memory loss since early life, but who are not demented. Specific diagnostic criteria have been proposed for AAMI and these criteria are now being applied in clinical studies, including a number of(More)
Normative data are provided on 1,106 subjects who were administered a memory self-rating scale. This scale includes 21 ability-to-remember items yielding 5 factors, 24 items assessing frequency-of-occurrence of memory failures yielding five factors, and four global rating items assessing overall comparison to others, comparison to the best one's memory has(More)