Thomas H. Bothwell

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The first recognised outbreak of Marburg virus disease in Africa, and the first since the original epidemic in West Germany and Yugoslavia in 1967, occurred in South Africa in February 1975. The primary case was in a young Australian man , who was admitted to the Johannesburg Hospital after having toured Rhodesia. Two secondary cases occurred, one being in(More)
Iron requirements are greater in pregnancy than in the nonpregnant state. Although iron requirements are reduced in the first trimester because of the absence of menstruation, they rise steadily thereafter; the total requirement of a 55-kg woman is approximately 1000 mg. Translated into daily needs, the requirement is approximately 0.8 mg Fe in the first(More)
A targeted, double-blind controlled iron fortification trial using Fe(111)-EDTA in masala (curry powder) was directed towards an Fe-deficient Indian population for 2 y. The Fe status of the fortified group improved more than that of control subjects. Improvement reached significance over control subjects for females in hemoglobin (p = 0.0005), ferritin (p =(More)
1. Non-haem iron absorption from a variety of vegetable meals was studied in parous Indian Women, using the erythrocyte utilization of radioactive Fe method. 2. The studies were undertaken to establish whether Fe absorption could be correlated with the chemical composition of the foodstuff. 3. Addition of the following organic acids commonly found in(More)
In normal adult males, about 25%o of the body iron content is in storage depots (1). This iron exists in two forms: as a diffuse soluble fraction called ferritin, in which the molecules are dispersed, and as insoluble aggregates of hemosiderin, which can be visualized by conventional microscopy (2). Although the liver is regarded as the chief storage organ,(More)