Thomas Geisler

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In research, pharmacologic drug-screening and medical diagnostics, the trend towards the utilization of functional assays using living cells is persisting. Research groups working with living cells are confronted with the problem, that common endpoint measurement methods are not able to map dynamic changes. With consideration of time as a further dimension,(More)
Addressing the increasing biomedical and pharmacological interest in multiparametric screening assays, a concept has been developed, which integrates multiparametric, bioelectric, and biochemical sensors for the analytical monitoring of intra- and extra cellular parameters and an automated imaging microscope for high-content screening into a single embedded(More)
INTRODUCTION The influence of heart rate on cardiac output, oxygen consumption, and myocardial activity has been widely investigated. However, the influence of heart rate on myocardial oxygen tension (pO2) remains unclear. Since the introduction of flexible pO2 micro catheters to measure partial oxygen tension in a working muscle, it is possible to(More)
The specific interaction of a supramolecular binding motif was quantitatively evaluated by dynamic single-molecule force spectroscopy (SMFS) using an atomic force microscope (AFM). The supramolecular capsule forms by two different cavitands stitched together by four hydrogen bonds between carboxylic acid and pyridyl groups. The tetra(carboxyl)cavitand is(More)
We present three recently developed photochromic fluorophores that are based on diarylethenes with elongated conjugated π-systems. The diarylethenes 1 and 3 can be switched from their open to their closed form with visible light. The diarylethenes 1 and 2 are covalently coupled to a standard rhodamine B-based fluorophore and act as photoswitchable resonance(More)
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