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Slow N-Methyl-D-aspartic acid (NMDA) synaptic currents are assumed to strongly contribute to the persistently elevated firing rates observed in prefrontal cortex (PFC) during working memory. During persistent activity, spiking of many neurons is highly irregular. Here we report that highly irregular firing can be induced through a combination of NMDA- and(More)
At least two rate-limiting mechanisms in vesicle trafficking operate at mouse Schaffer collateral synapses, but their molecular/physical identities are unknown. The first mechanism determines the baseline rate at which reserve vesicles are supplied to a readily releasable pool. The second causes the supply rate to depress threefold when synaptic(More)
Learning rule systems from real-world data often generate too many rules for human interpretation. Hierarchical rule systems with only a small number of rules at each level can help to overcome this issue: Lower levels in this hierarchy focus on areas of the feature space where only weak evidence for a rule is found in the data. Rules further up, at higher(More)
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