Thomas G Landry

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OBJECTIVE To evaluate the cognitive effects of topiramate (TPM) and gabapentin (GBP). METHODS Forty healthy volunteers were randomized to a 12-week course of TPM, GBP, or placebo. Doses were gradually escalated over 10 weeks to a maximum of 400 mg/day of TPM or 3,600 mg/day of GBP or to the highest tolerated dose. Subjects were interviewed and examined(More)
We have previously shown that neonatal deafness of 7-13 months duration leads to loss of cochleotopy in the primary auditory cortex (AI) that can be reversed by cochlear implant use. Here we describe the effects of a similar duration of deafness and cochlear implant use on temporal processing. Specifically, we compared the temporal resolution of neurons in(More)
Cochlear implants restore hearing cues in the severe-profoundly deaf by electrically stimulating spiral ganglion neurons (SGNs). However, SGNs degenerate following loss of cochlear hair cells, due at least in part to a reduction in the endogenous neurotrophin (NT) supply, normally provided by hair cells and supporting cells of the organ of Corti. Delivering(More)
Cochlear implants electrically stimulate residual spiral ganglion neurons (SGNs) to provide auditory cues for the severe-profoundly deaf. However, SGNs gradually degenerate following cochlear hair cell loss, leaving fewer neurons available for stimulation. Providing an exogenous supply of neurotrophins (NTs) has been shown to prevent SGN degeneration, and(More)
HYPOTHESIS Round window reinforcement leads to conductive hearing loss. BACKGROUND The round window is stiffened surgically as therapy for various conditions, including perilymphatic fistula and superior semicircular canal dehiscence. Round window reinforcement reduces symptoms in these patients. However, it also reduces fluid displacement in the cochlea(More)
HYPOTHESIS The use of larger-diameter pistons in stapedotomy leads to better hearing outcomes compared with the use of smaller-diameter pistons. There is an interaction between stapes piston diameter and fenestration diameter. BACKGROUND Otosclerosis can be treated surgically by removing part of the stapes and bypassing the stapes footplate with a(More)
HYPOTHESIS To illustrate the ability of high frequency ultrasound (HFUS) using a transducer array to demonstrate a variety of simulated clinical scenarios involving the ossicular chain. BACKGROUND HFUS (>20 MHz) is a relatively new area of ultrasonic imaging that provides an order of magnitude better image resolution than the conventional low-frequency(More)
Imaging techniques currently used in the clinic to inspect ears in patients are generally limited to views terminating at the tympanic membrane (TM) surface. For imaging past the TM, methods such as computed tomography are typically used, but in addition to disadvantages such as being costly, time consuming, and causing radiation exposure, these often do(More)
In Eastern Canada, an increasing number of pests, predators and pathogens in downriver areas (close to the ocean) have led the aquaculture industry to consider growing oysters in upriver areas (close to the river source). In this study, oyster growth performance was compared between downriver and upriver environments by means of stock transfer experiments(More)
Rats were exposed to 20 mg/kg methylmercury for 10-18 days. The isolated phrenic nerve-hemidiaphragms from these animals demonstrated a reduced capability to maintain contraction amplitude when stimulated at a frequency of 10/sec. The addition of neostigmine directly to the organ bath produced a contraction enhancement significantly lower than normal. In a(More)
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