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We study a stochastic nonlocal partial differential equation, arising in the context of modelling spatially distributed neural activity, which is capable of sustaining stationary and moving spatially localized ‘activity bumps’. This system is known to undergo a pitchfork bifurcation in bump speed as a parameter (the strength of adaptation) is changed; yet… (More)

- Radek Erban, Thomas A Frewen, +4 authors Ioannis G Kevrekidis
- The Journal of chemical physics
- 2007

Finding coarse-grained, low-dimensional descriptions is an important task in the analysis of complex, stochastic models of gene regulatory networks. This task involves (a) identifying observables that best describe the state of these complex systems and (b) characterizing the dynamics of the observables. In a previous paper [R. Erban et al., J. Chem. Phys.… (More)

- Carlo R. Laing, Thomas Frewen, Ioannis G. Kevrekidis
- Journal of Computational Neuroscience
- 2010

Binocular rivalry occurs when two very different images are presented to the two eyes, but a subject perceives only one image at a given time. A number of computational models for binocular rivalry have been proposed; most can be categorised as either “rate” models, containing a small number of variables, or as more biophysically-realistic “spiking neuron”… (More)

- Allison Kolpas, Jeff Moehlis, Thomas A Frewen, Ioannis G Kevrekidis
- Mathematical biosciences
- 2008

We study the effects of a signalling constraint on an individual-based model of self-organizing group formation using a coarse analysis framework. This involves using an automated data-driven technique which defines a diffusion process on the graph of a sample dataset formed from a representative stationary simulation. The eigenvectors of the graph… (More)

The coarse-grained, computer-assisted analysis of models of collective dynamics in animal groups involves (a) identifying appropriate observables that best describe the state of these complex systems and (b) characterizing the dynamics of such observables. We devise “equation-free” simulation protocols for the analysis of a prototypical individual-based… (More)

- Thomas A Frewen, Gerhard Hummer, Ioannis G Kevrekidis
- The Journal of chemical physics
- 2009

We describe a reverse integration approach for the exploration of low-dimensional effective potential landscapes. Coarse reverse integration initialized on a ring of coarse states enables efficient navigation on the landscape terrain: Escape from local effective potential wells, detection of saddle points, and identification of significant transition paths… (More)

- Thomas A. Frewen
- 2015

The density and spatial distribution of oxide precipitates within a crystalline silicon wafer is of paramount importance for microelectronic device yield. In this letter, the authors show how the formation of previously unconsidered, very small vacancy aggregates can explain macroscopic spatial variations in the oxide precipitate density, which are observed… (More)

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