Thomas Franz

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The Semantic Web fosters novel applications targeting a more efficient and satisfying exploitation of the data available on the web, e.g. faceted browsing of linked open data. Large amounts and high diversity of knowledge in the Semantic Web pose the challenging question of appropriate relevance ranking for producing fine-grained and rich descriptions of(More)
One of the key factors that hinders integration of distributed, heterogeneous information systems is the lack of a formal basis for modeling the complex, structured knowledge that is to be exchanged. To alleviate this situation, we present an approach based on core ontologies. Core ontologies are characterized by a high degree of axiomatization and formal(More)
The lack of a formal model of events hinders interoperability in distributed event-based systems. In this paper, we present a formal model of events, called Event-Model-F. The model is based on the foundational ontology DOLCE+DnS Ultralight (DUL) and provides comprehensive support to represent time and space, objects and persons, as well as mereological,(More)
Events are central aspect of many semantic ambient media applications such as surveillance, smart homes, automobiles, and others. Existing models for events typically do not follow a systematic development approach, are conceptually narrow with respect to event features, and their semantics is often ambiguous. This makes the communication between and(More)
This work was concerned with the numerical simulation of the behaviour of aortic valves whose material can be modelled as non-linear elastic anisotropic. Linear elastic models for the valve leaflets with parameters used in previous studies were compared with hyperelastic models, incorporating leaflet anisotropy with pronounced stiffness in the(More)
AIMS A living heart valve with regeneration capacity based on autologous cells and minimally invasive implantation technology would represent a substantial improvement upon contemporary heart valve prostheses. This study investigates the feasibility of injectable, marrow stromal cell-based, autologous, living tissue engineered heart valves (TEHV) generated(More)
Heart valve tissue engineering based on decellularized xenogenic or allogenic starter matrices has shown promising first clinical results. However, the availability of healthy homologous donor valves is limited and xenogenic materials are associated with infectious and immunologic risks. To address such limitations, biodegradable synthetic materials have(More)
OBJECTIVE External mesh support of vein grafts has been shown to mitigate the formation of intimal hyperplasia. The aim of the present study was to address the issue of optimal mesh size in a nonhuman primate model that mimics the dimensional mismatch typically encountered between clinical vein grafts and their target arteries. METHODS The effect of mesh(More)
Extracellular mimetic hydrogels formed from peptide crosslinkers and polyethylene glycol monomers permit cell-controlled invasion. The use of matrix metalloproteinase specific peptides might further allow for selective control of different cell-type invasion. In this study, the invasion of fibroblasts and vascular smooth muscle cells (VSMC) into hydrogels(More)
Die Arbeitsberichte aus dem Fachbereich Informatik dienen der Darstellung vorläufiger Ergebnisse, die in der Regel noch für spätere Veröffentlichungen überarbeitet werden. Die Autoren sind deshalb für kritische Hinweise dankbar. Alle Rechte vorbehalten, insbesondere die der Übersetzung, des Nachdruckes, des Vortrags, der Entnahme von Abbildungen und(More)