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The Semantic Web fosters novel applications targeting a more efficient and satisfying exploitation of the data available on the web, e.g. faceted browsing of linked open data. Large amounts and high diversity of knowledge in the Semantic Web pose the challenging question of appropriate relevance ranking for producing fine-grained and rich descriptions of(More)
Gephyrin is a bi-functional modular protein involved in molybdenum cofactor biosynthesis and in postsynaptic clustering of inhibitory glycine receptors (GlyRs). Here, we show that full-length gephyrin is a trimer and that its proteolysis in vitro causes the spontaneous dimerization of its C-terminal region (gephyrin-E), which binds a GlyR(More)
Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation has been implicated in a wide range of diseases. Here we demonstrate that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like receptor')-dependent control of neuronal(More)
Maternal trauma (MT) in automotive collisions is a source of injury, morbidity, and mortality for both mothers and fetuses. The primary associated pathology is placental abruption in which the placenta detaches from the uterus leading to hemorrhaging and termination of pregnancy. In this study, we focused on the differences in placental tissue response to(More)
The lack of a formal model of events hinders interoperability in distributed event-based systems. In this paper, we present a formal model of events, called Event-Model-F. The model is based on the foundational ontology DOLCE+DnS Ultralight (DUL) and provides comprehensive support to represent time and space, objects and persons, as well as mereological,(More)
In this paper, we present X-COSIM, a framework for cross context semantic information management consisting of the ontology X-COSIMO and the application programming interface X-COSIMA. X-COSIM provides what is lacking in current semantic desktops: A consistent seamless integration of a conceptually broad reference model and context dependent(More)
While instant messaging (IM) became a mature communication means in business organizations over the last years, IM systems did not follow this evolution comparably. Communicated content is often stored insufficiently and hard to recall, integration into other desktop applications impossible. In this paper, we address these shortcomings and provide concepts(More)
We present LENA, a web-based RDF browser that supports the rendering of complex RDF data, including in-terlinked data available on the Semantic Web, based on criteria expressed as SPARQL queries. The user interface of LENA enables to switch between different views onto the presented data enabling users to browse with respect to individual interests or(More)